Expression of miR-148b-3p is correlated with overexpression of biomarkers in prostate cancer

Genetics and Molecular Biology
Eliakym Arámbula-MerazNoemí García-Magallanes

Abstract

Prostate cancer (PCa) is one of the leading causes of death among men. Genes such as PCA3, PSA, and Fra-1 are suggested to serve as potential tools for the detection of PCa, as they are deregulated during this pathology. A similar event occurs with small non-coding RNAs, called miRNAs, specifically miR-195-5p, miR-133a-3p, and miR-148b-3p, which were analyzed in a Chinese population and suggested to be possible candidates for PCa diagnosis. We evaluated the expression levels of three miRNAs and three genes in tissue samples of PCa and benign prostate disease, such as benign prostatic hyperplasia, or prostatitis, in order to determine their potential as candidates for PCa detection. Our results showed a statistically significant overexpression of 279-fold increase in PSA levels and a 1,012-fold increase in PCA3 levels in PCa patients compared to benign prostate disease patients (p = 0.001 and p = 0.002, respectively). We observed a positive correlation between the expression of miR-148b-3p and the expression of PSA and PCA3 genes, two established biomarkers in PCa. The expression of miR-148b-3p was not related to clinical characteristics, such as age and weight, as observed for the other miRNAs analyzed, suggesting its potential...Continue Reading

References

Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Apr 22, 2006·Cell Cycle·Cynthia Bradham, David R McClay
Oct 29, 2008·Evidence-based Complementary and Alternative Medicine : ECAM·Ravikumar AalinkeelStanley A Schwartz
May 15, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Teng XuShi-Mei Zhuang
Jun 19, 2009·Nature Reviews. Molecular Cell Biology·Stephane Angers, Randall T Moon
Jul 25, 2009·Nature Reviews. Cancer·Erwin F Wagner, Angel R Nebreda
Feb 26, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Dan LiLihui Lai
Apr 19, 2011·The Journal of Urology·Alexandre de la TailleAlexander Haese
Oct 8, 2011·PloS One·Akira WatahikiYuzhuo Wang
Jun 23, 2012·Cold Spring Harbor Perspectives in Biology·Jemima L WhyteJill A Helms
Jul 27, 2012·Journal of Human Genetics·Gabriela Martínez-CortésHéctor Rangel-Villalobos
Jun 20, 2013·Journal of Cancer·Beatriz A WalterMaria J Merino
Jan 15, 2014·Cancer Metastasis Reviews·Jennifer Wu, Evan Yu
Dec 3, 2014·Journal of Cancer Research and Therapeutics·Wu-Jin XueYe-Hui Xu
Dec 19, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Muhammad DaniyalAsmatullah Khan
Jan 22, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Seyed Hamid Aghaee-BakhtiariMasoud Soleimani
Jun 18, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Chao CaiChin-Lee Wu
Sep 5, 2015·Journal of Experimental & Clinical Cancer Research : CR·Jia GuoXiuheng Liu
Nov 5, 2015·Genetics and Molecular Research : GMR·F Fonseca CoelhoK Braga Gomes
Mar 31, 2017·In Vivo·Seda Gulec YilmazTurgay Isbir
Sep 13, 2017·Nature Reviews. Urology·Virginia Murillo-Garzón, Robert Kypta
Jul 5, 2018·Journal of Cancer Research and Therapeutics·Meifeng LiXiaoqing Zhou

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
PCR
biopsies

Software Mentioned

NormFinder
Statistical Package for the Social Sciences ( SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Chinese Journal of Cancer Research = Chung-kuo Yen Cheng Yen Chiu
Zheng YangZhe Wang
Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
I Casanova-SalasJ A Lopez-Guerrero
© 2021 Meta ULC. All rights reserved