Expression of miR-200c and its clinicopathological significance in patients with colorectal cancer

Pathology, Research and Practice
Mee Sook RohMee-Seon Kim

Abstract

MicroRNA-200c (miR-200c) is known to play a pivotal role in the regulation of epithelial-to-mesenchymal and mesenchymal-to-epithelial transition processes. However, the biological function of miR-200c in human carcinogenesis remains controversial. We examined the association of miR-200c expression with various clinicopathological factors, including KRAS mutation status and survival, in patients with colorectal cancer (CRC). The expression level of miR-200c was evaluated in 109 paired CRC and normal tissue samples using quantitative reverse transcription polymerase chain reaction. The KRAS mutation status of the CRC samples was determined using the PNAClamp™ KRAS Mutation Detection kit. Compared with the normal tissue group, miR-200c expression was significantly upregulated in the CRCs (P < .001). The expression of miR-200c was increased in CRCs with higher grade (P = .009), advanced stage (P = .042), and lymphovascular invasion (P = .003). Thirty-one CRCs (28.4%) had KRAS mutations in codon 12 or 13. CRCs with KRAS mutations had significantly higher miR-200c expression than CRCs with wild-type KRAS (P = .003). In survival analysis, high miR-200c expression was correlated with worse overall survival (P = .017) and recurrence-fre...Continue Reading

Citations

Oct 19, 2019·Journal of Clinical Medicine·Branislava RankovićEmanuela Boštjančič
Nov 25, 2018·International Journal of Molecular Sciences·Ovidiu BalacescuAlexandru Irimie
Nov 30, 2018·Journal of Cellular Physiology·Saeed NoorolyaiBehzad Baradaran
Jan 3, 2021·Cellular Signalling·Neda YaghoubiSeyed Hamid Aghaee-Bakhtiari
Jul 21, 2020·Oncology Reviews·Hamizah Ibrahim, Ya Chee Lim
Feb 19, 2021·Molecular Biology Reports·Igor Lopes Dos SantosVera Aparecida Saddi
May 23, 2021·Human Immunology·Elham BaghbaniBehzad Baradaran
Jul 3, 2021·Cancers·Paulína Pidíková, Iveta Herichová

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