Expression of miR-208b and miR-499 in Greek Patients with Acute Myocardial Infarction

In Vivo
Konstantinos AgiannitopoulosKlea Lamnissou

Abstract

Certain microRNAs (miRs) present in human plasma are candidate biomarkers for cardiovascular diseases, including acute myocardial infarction (AMI). We examined the expression of two cardiac-specific miRs (miR-208b and miR-499) in a Greek pathological population. Plasma samples from AMI patients and healthy subjects (controls) were analyzed using TaqMan® MicroRNA assays. The concentration of both miRs was significantly elevated in AMI patients compared to healthy controls. Moreover, receiver-operating characteristic (ROC) curve analysis showed that miR-208b and miR-499 displayed similar properties with the established AMI biomarker cardiac troponin T (cTnT). We showed, for the first time, that these miRs could be used as AMI biomarkers in our population as well. Our data are in agreement with those of studies based on different population groups and further strengthen the observation that plasma levels of circulating miR-208b and miR-499 could serve as potential AMI biomarkers.

Citations

Apr 28, 2020·BioMed Research International·Lijie Wang, Yuanzhe Jin
Oct 13, 2021·Applied Biochemistry and Biotechnology·Marwa A GaberAbdel-Raheim M A Meki

❮ Previous
Next ❯

Related Concepts

Related Feeds

Biomarkers for Cardiovascular Risk Assessment

Sensitive and accurate biomarkers used in cardiovascular risk prediction can potentially be used to manage the risk of cardiovascular disease. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here.