Expression of Mitochondria-Associated Genes (PPARGC1A, NRF-1, BCL-2 and BAX) in Follicular Development and Atresia of Goat Ovaries

Reproduction in Domestic Animals = Zuchthygiene
G ZhangF Wang

Abstract

Most follicles undergo atresia during the developmental process. Follicular atresia is predominantly regulated by apoptosis of granulosa cells, but the mechanism underlying apoptosis via the mitochondria-dependent apoptotic pathway is unclear. We aimed to investigate whether the mitochondria-associated genes peroxisome proliferator-activated receptor-gamma, coactivator1-alpha (PPARGC1A), nuclear respiratory factor-1 (NRF-1), B-cell CLL/lymphoma 2 (BCL-2) and BCL2-associated X protein (BAX) played a role in follicular atresia through this pathway. The four mitochondria-associated proteins (PGC-1α, which are encoded by the PPARGC1A gene, NRF-1, BCL-2 and BAX) mainly expressed in granulosa cells. The mRNA and protein levels of PPARGC1A/PGC-1α and NRF-1 in granulosa cells increased with the follicular development. These results showed that these genes may play a role in the regulation of the follicular development. In addition, compared with healthy follicles, the granulosa cell in atretic follicles had a reduced expression of NRF-1, increased BAX expression and increased ratio of BAX to BCL-2 expression. These results suggested that changes of the mitochondria-associated gene expression patterns in granulosa cells may lead to foll...Continue Reading

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Citations

Aug 27, 2016·Human Reproduction Update·Pascale May-PanloupPascal Reynier
Nov 30, 2016·Journal of Bioenergetics and Biomembranes·Guo-Min ZhangZhi-Hai Lei
Jun 19, 2017·Reproduction : the Official Journal of the Society for the Study of Fertility·Guo-Min ZhangYan-Li Zhang
Feb 26, 2020·Veterinary Pathology·Naoyuki FukeRyoji Yamaguchi
May 16, 2020·Journal of Biochemical and Molecular Toxicology·Manman LiDagan Mao
Jul 29, 2015·World Journal of Gastroenterology : WJG·Hai-Bo ZhouZhi-Gang Chen

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