Expression of MMP-1 in invasive well-differentiated thyroid carcinoma.

European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
Aviram MizrachiJacob Shvero

Abstract

The objective of this study is to examine the expression of matrix metalloproteinase 1 (MMP-1) in invasive well-differentiated thyroid carcinoma (WDTC) and its relation to clinicopathological features. This retrospective case study group included 26 patients with invasive WDTC who were treated at our center between January 1985 and May 2007. Clinical data were collected from the medical files. MMP-1 expression was tested in samples from paraffin-embedded tumor by immunohistochemical staining. MMP-1 expression correlated with laryngotracheal invasion (p = 0.032), multifocality of the tumor (p = 0.044), and presence of regional (p = 0.034) and distant metastases (p = 0.048). In conclusion, the expression of MMP-1 in invasive WDTC is consistent with tumor aggressiveness, manifested by laryngotracheal invasion, multifocality, and regional and distant metastases. MMP-1 expression may serve as a prognostic marker and an indicator for the need for more aggressive surgical treatment.

References

Dec 1, 1992·American Journal of Surgery·J P ShahV Vlamis
Jan 1, 1996·Pathology, Research and Practice·K Kameyama
Sep 17, 1998·The Laryngoscope·S W BaylesG W Carlson
Feb 24, 2001·Thyroid : Official Journal of the American Thyroid Association·Z Kraiem, S Korem
Apr 12, 2001·The Journal of Clinical Endocrinology and Metabolism·E L Mazzaferri, R T Kloos
Feb 19, 2002·International Journal of Radiation Oncology, Biology, Physics·Sin Ming ChowWai Hon Lau
Jul 21, 2004·Archives of Otolaryngology--head & Neck Surgery·Carsten E PalmeJeremy L Freeman
Nov 27, 2004·The Laryngoscope·Sharon L CushingJeremy L Freeman
Jan 27, 2005·Thyroid : Official Journal of the American Thyroid Association·E BaldiniM D'Armiento
Apr 29, 2005·American Journal of Otolaryngology·Richard O Wein
Jun 24, 2005·American Journal of Surgery·Peter ZbärenEdouard Stauffer
Dec 22, 2005·Frontiers in Bioscience : a Journal and Virtual Library·Charles J Malemud
Jan 10, 2006·The International Journal of Biological Markers·M D CorteF Vizoso
Jan 21, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Henni RuokolainenTaina Turpeenniemi-Hujanen
Feb 20, 2007·World Journal of Surgery·Ashok R Shaha
Jan 8, 2008·Surgical Oncology Clinics of North America·Nebil ArkRandal S Weber
Feb 5, 2008·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Paolo MiccoliFulvio Basolo
Mar 26, 2008·European Journal of Endocrinology·Stéphane BardetMichel Henry-Amar

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Citations

May 18, 2016·Journal of Cellular Physiology·Rahul MittalXue Zhong Liu

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