Expression of MMP-10, MMP-21, MMP-26, and MMP-28 in Merkel cell carcinoma.

Virchows Archiv : an International Journal of Pathology
Sari SuomelaUlpu Saarialho-Kere

Abstract

Merkel cell carcinoma (MCC) is an aggressive cutaneous tumor with poor outcome and increasing incidence. We examined by immunohistochemistry the expression of three novel matrix metalloproteinases (MMPs)-MMP-21, MMP-26, and MMP-28-in 44 primary MCC tumors and six lymph node metastases while MMP-10 served as a positive control. Their mRNA expression was also studied in the UISO MCC cell line basally and after various stimulations using quantitative real-time PCR. MMP-28 was observed in tumor cells of 15/44 samples especially in tumors <2 cm in diameter (p = 0.015) while 21/44 specimens showed MMP-28 in the tumor stroma. Expression of MMP-21 was demonstrated in tumor cells of 13/43 samples. MMP-26, instead, was positive in stromal cells (17/44) and its expression associated with tumors >or=2 cm in diameter (p = 0.006). Stromal expression of MMP-10 was the most frequent finding of the studied samples (31/44), but MMP-10 was detected also in tumor cells (17/44). Most of the metastatic lymph nodes expressed MMP-10 and MMP-26. MMP-10, MMP-21, and MMP-28 mRNAs were basally expressed by the UISO cells, and the corresponding proteins were detectable by immunostaining of cultured cells. IFN-alpha and TNF-alpha downregulated MMP-21 and MM...Continue Reading

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Citations

Jul 21, 2012·The American Journal of Dermatopathology·Marier Hernández-Pérez, Meera Mahalingam
Oct 3, 2015·Journal of Medical Genetics·Zeev PerlesNicholas Katsanis
Oct 23, 2013·Seminars in Diagnostic Pathology·Marie Abi DaoudDanny Ghazarian
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May 18, 2016·Journal of Cellular Physiology·Rahul MittalXue Zhong Liu
Sep 15, 2018·Experimental and Therapeutic Medicine·Xuepeng WangJinfeng Pang

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