Expression of MMP-2 and MMP-9 in odontogenic myxoma in a child: report of a clinical case.

Odontology
Annamaria MauroMaria Buscemi

Abstract

Odontogenic myxoma (OM) is a benign, locally invasive, non-metastasizing neoplasm of the jaw bones. Despite the benign nature of these lesions, there is a high rate of recurrence and the current recommended therapy, depending on the size and behaviour of the lesion, can vary from curettage with peripheral ostectomy, segmental resection up to radical resections for more aggressive lesions. OM is a rare tumour which occurs predominantly in the third decade of life and it is rare in children. Matrix metalloproteinases (MMPs) are a family of extracellular endopeptidases responsible for the degradation and remodelling of extracellular matrix, they are known to be involved in the progression and invasiveness of many types of tumour. MMPs have been studied in OM because of their well-known role in extracellular matrix degradation, tumour invasion and recurrence. We report a case of OM in a 6-year-old boy. A conservative excision was accomplished. The mass was excised without affecting the mandibular bone and the inferior alveolar nerve. Curettage and removal of the first right inferior molar were performed. After 6-month follow-up, no evidence of recurrence was found. We investigated the expression of MMP-2 and MMP-9 in this case of O...Continue Reading

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Citations

Apr 9, 2014·BMC Research Notes·Yoko Kawase-KogaYoshiyuki Mori
Aug 28, 2020·BMJ Case Reports·Suman BislaVirendra Singh
Nov 1, 2020·BMJ Case Reports·Raymond Patrick Shupak, Jason J Cho

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