PMID: 11934016Apr 6, 2002Paper

Expression of MMP1 in surgical and radiation-impaired wound healing and its effects on the healing process

Journal of Environmental Pathology, Toxicology and Oncology : Official Organ of the International Society for Environmental Toxicology and Cancer
Qingyang GuMeilan Zhao

Abstract

Radiation-impaired wound is characterized by delayed healing, nonhealing, and carcinogenesis. The mechanism remains unclear. Matrix metalloproteinases (MMPs) are one family of key regulators of the process of wound healing. Their abnormal expression plays important roles in the formation of some chronic skin ulcers. The objective of this project was to study the expression of MMP1 in surgical and radiation-impaired wound healing and its effects on the healing process and tissue remodeling. A rat model of radiation-impaired wound healing was used. Routine light microscopy, electron microscopy, immunohistochemistry, and in situ hybridization, all of which enabled the detection of MMP1 expression during the healing process, were performed. The wound healing process was impaired and delayed. In rats receiving 25Gy gamma-ray locally, the irradiated wounds healed 6 days later than the nonirradiated controls. The following changes in MMP1 expression were found: (1) In the early inflammatory phase and in the period of granulation tissue formation, MMP1 expression was only slightly if at all affected in the newly formed epidermis of irradiated wounds compared with controls. Later, the epidermal expression of MMP1 in radiation wounds was...Continue Reading

Citations

Dec 31, 2003·Biomaterials·E MiddelkoopM M W Ulrich
Nov 24, 2004·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Wanda A Dorsett-Martin
Sep 26, 2012·Radiation Oncology·Frank HaubnerHolger G Gassner
Sep 2, 2014·The Veterinary Clinics of North America. Small Animal Practice·Sarah Boston, Ralph A Henderson
Feb 2, 2013·Facial Plastic Surgery Clinics of North America·Jeffrey J Houlton, David B Hom
Feb 12, 2009·Journal of Clinical Periodontology·Ricardo GapskiWilliam V Giannobile
Aug 25, 2010·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Ge ZhaoJohn E Olerud
May 9, 2012·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Ge ZhaoJohn E Olerud
Dec 17, 2008·Journal of Surgical Oncology·Miriam Lurie

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