Abstract
The synovitis of rheumatoid arthritis (RA) is one of few pathological lesions in which B lymphocyte accumulation progresses to the extent of germinal centre formation. The present study was designed to assess the ability of synovial fibroblasts to express molecules implicated in B lymphocyte survival and differentiation, both in vivo, and in response to cytokines in vitro. Normal and diseased synovia were examined by indirect immunofluorescence. In all tissues synovial intimal fibroblasts showed co-expression of vascular cell adhesion molecule-1 (VCAM-1) and complement decay-accelerating factor (DAF) comparable to that of follicular dendritic cells (FDC), but not complement receptor 2 (CR2). In rheumatoid synovia, subintimal cells showed variable expression of VCAM-1 and DAF, with bright co-expression of VCAM-1, DAF and CR2 in lymphoid follicle centres. B lymphocytes, some of which were proliferating cell nuclear antigen-positive, were present in contact with subintimal cells expressing VCAM-1 with or without DAF or CR2. B lymphocytes were rarely present in the intimal layer, and, where present, showed fragmentation. In vitro, synovial fibroblasts exposed to tumour necrosis factor-alpha (TNF-alpha) in combination with interfero...Continue Reading
Citations
Aug 14, 1999·Immunology·J C EdwardsV M Abrahams
Feb 13, 2001·The Journal of Clinical Investigation·J A BurgerT J Kipps
Aug 6, 1998·The Journal of Clinical Investigation·Y ShimaokaP E Lipsky
Nov 30, 2000·Arthritis Research·J C Edwards
Jul 14, 2012·PloS One·Marta Benito-MiguelMaría-Eugenia Miranda-Carús
Mar 25, 2008·Therapeutics and Clinical Risk Management·Adam Bryant, John Moore
May 12, 2005·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Adam MorMichael H Pillinger
Nov 1, 2008·Seminars in Arthritis and Rheumatism·Jean-Marie BerthelotYves Maugars
May 6, 2008·Best Practice & Research. Clinical Rheumatology·Daniëlle M Gerlag, Paul P Tak
Jan 20, 2007·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Naren M H Ravindranath, Charles Shuler
May 7, 2011·Arthritis and Rheumatism·Elena IzquierdoJosé L Pablos
Oct 27, 2006·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·D Mewar, A G Wilson
Aug 23, 2005·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Chinh N TranDavid A Fox
Jun 25, 2005·Cytokine·Bruno SchnyderRené Moser
Jan 6, 2001·The American Journal of Pathology·P F HalloranN M Kneteman
Dec 25, 2013·Journal of Autoimmunity·G CambridgeJ C W Edwards
Apr 14, 2016·Annals of the Rheumatic Diseases·Priscilla F KerkmanHans U Scherer
Mar 21, 2001·Rheumatology·J C Edwards, G Cambridge
Aug 15, 1998·Arthritis and Rheumatism·T SekiR Winchester
Mar 17, 2004·Arthritis and Rheumatism·Elena A JonesDennis McGonagle
Jul 13, 2004·Arthritis and Rheumatism·Andrea BraunCornelia M Weyand
Jul 13, 2002·Arthritis and Rheumatism·J E FonsecaN J Goulding
Nov 14, 2012·Nature Reviews. Rheumatology·Nunzio Bottini, Gary S Firestein
Dec 31, 1998·Arthritis and Rheumatism·C C Reparon-SchuijtC L Verweij
Aug 12, 2014·Journal of Medicinal Chemistry·Shreyans K JainRam A Vishwakarma