PMID: 8590453Apr 1, 1995Paper

Expression of mRNAs of multiple growth factors and receptors by astrocytes and glioma cells: detection with reverse transcription-polymerase chain reaction

Cellular and Molecular Neurobiology
A ZaheerR Lim

Abstract

1. Although glial cells in culture are known to secrete growth factors and are also known to be responsive to some of them, detailed comparisons are difficult because the bulk of information was based on various animals of origin, developmental stages, growth properties, culture age, and culture conditions. 2. To present a unified picture of the growth factors and their receptors found in glial cells, we surveyed the expression of messenger RNAs of a panel of growth factors and receptors, using reverse transcription-polymerase chain reaction (RT-PCR), in three common glial cell types: rat astrocytes in primary culture, rat glioma line C6, and human glioma line A172. 3. We observed that normal and neoplastic glial cells in culture express multiple growth factors and also possess most of the receptors to the factors, suggesting multiple autocrine functions. In addition, glia produce growth factors known to be capable of acting on neurons, implicating paracrine function involving glia-neuron interaction. Glial cells also produce growth factors and receptors that are capable of communicating with hematopoietic cells, suggesting neuroimmunologic interaction. What is most interesting is that glial cells express receptors for growth f...Continue Reading

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Citations

Mar 21, 2000·Journal of Neuroscience Research·S KuklinskiR Probstmeier
Mar 25, 2000·Neurochemistry International·H K KimelbergM Zhou
Jun 5, 2004·Parkinsonism & Related Disorders·C KnottG P Wilkin
Jun 23, 1999·Proceedings of the National Academy of Sciences of the United States of America·D A Lim, A Alvarez-Buylla
Oct 16, 2007·Journal of the Neurological Sciences·Jacques De KeyserMarcus W Koch
May 3, 2005·Brain Research. Developmental Brain Research·Marieke E van MeeterenEric A F van Tol
Dec 18, 2013·Translational Neuroscience·Angela LanciottiElena Ambrosini
Jun 11, 2009·Biomedit︠s︡inskai︠a︡ khimii︠a︡·V P BaklaushevV P Chekhonin
Dec 8, 2006·Neurochemical Research·Asgar ZaheerRamon Lim

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