Expression of MUC1 and MUC2 mucins in epithelial ovarian tumours

The Journal of Pathology
Y DongM A McGuckin

Abstract

This is the first study to describe the association between expression of MUC1 and MUC2 mucins and prognosis in ovarian cancer. Paraffin sections of epithelial ovarian tumours (n = 182: 29 benign, 21 low malignant potential, and 132 invasive tumours) were analysed immunohistochemically for expression of MUC1 and MUC2 mucin core proteins. Most benign, low malignant potential, and invasive tumours showed high MUC1 expression in the cytoplasm. Low cytoplasmic expression of MUC1 was a predictor for good prognosis, particularly within stage III tumours. A minority of benign epithelial tumours, but most low malignant potential and invasive non-mucinous tumours, showed high MUC1 expression on the cell membrane. High apical MUC1 reactivity was associated with non-mucinous tumours. Low expression of MUC1 in the apical membrane was associated with early stage and good outcome for invasive tumours. Most benign and low malignant potential tumours, but only a minority of invasive tumours, showed MUC2 expression. MUC2 was found in non-mucinous as well as in mucinous tumours. The presence of MUC2 was inversely associated with high tumour grade but was not associated with altered survival. These results support experimental evidence that MUC1 ...Continue Reading

References

Sep 1, 1992·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·P L Devine, I F McKenzie
Dec 11, 1992·American Journal of Respiratory Cell and Molecular Biology·J R Gum
May 6, 1992·Journal of the National Cancer Institute·P X XingI F McKenzie
Jan 1, 1990·Virchows Archiv. A, Pathological Anatomy and Histopathology·N J BallD D Snider
Jan 1, 1991·The Journal of Clinical Investigation·B H JanyC B Basbaum
May 1, 1990·Experimental Eye Research·B S Lewis, J J Harding
Jun 15, 1989·International Journal of Cancer. Journal International Du Cancer·A GirlingJ Taylor-Papadimitriou
Jun 1, 1989·Immunology and Cell Biology·P X XingI F McKenzie
Nov 11, 1993·International Journal of Cancer. Journal International Du Cancer·M R PriceS J Tendler
Nov 3, 1995·International Journal of Cancer. Journal International Du Cancer·M A McGuckinB G Ward
Mar 23, 1995·Cancer Letters·J HilkensC Patriarca
Jan 1, 1995·Annual Review of Physiology·S J Gendler, A P Spicer
Mar 1, 1994·British Journal of Urology·M D WalshM A McGuckin
Oct 1, 1993·Journal of Clinical Pathology·M D WalshR G Wright
Jun 1, 1993·British Journal of Cancer·P L DevineB G Ward

❮ Previous
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Citations

May 22, 2008·Acta Histochemica Et Cytochemica·Kenichi HirabayashiRobert Yoshiyuki Osamura
Jan 30, 2009·BMC Cell Biology·Susan FanayanJennifer A Byrne
Sep 9, 2010·Cancer Immunology, Immunotherapy : CII·Julia PinkhasovPinku Mukherjee
Apr 1, 2011·Molecular Cancer Research : MCR·Diane M MaherSubhash C Chauhan
Mar 19, 2013·Journal of Translational Medicine·Gregory T WurzMichael W DeGregorio
Sep 7, 2007·Cancer Biotherapy & Radiopharmaceuticals·Angèle L M OeiWim J G Oyen
Aug 1, 2008·Expert Opinion on Medical Diagnostics·Subhankar ChakrabortySurinder K Batra
Dec 8, 2006·Expert Opinion on Biological Therapy·Ronald J Buckanovich
Nov 18, 2008·The Lancet Oncology·Ajay P SinghSurinder K Batra
Mar 16, 2007·Human Pathology·Michael D WalshMichael A McGuckin
Mar 27, 2003·BJU International·D P ScholfieldM C Bishop
Nov 12, 2009·BioFactors·Satyanarayana RachaganiSurinder K Batra
Oct 11, 2008·Pathology International·Mika SugaiMakoto Naito
Jul 29, 2008·International Journal of Cancer. Journal International Du Cancer·Angèle L M OeiSilvia von Mensdorff-Pouilly
May 11, 2010·The Journal of Pathology·Ziqiang ZhangChunxue Bai
Jan 18, 2005·International Immunopharmacology·Vladimir M PisarevSimon Sherman
Aug 3, 2005·Gynecologic Oncology·Daniel G RosenRobert C Bast
Feb 12, 2008·Cancer Letters·Annalisa GervasoniOrnella Parolini
Jan 11, 2013·Cell Adhesion & Migration·Teresa M Horm, Joyce A Schroeder
Dec 26, 2009·Journal of Ovarian Research·Subhash C ChauhanMeena Jaggi
Apr 14, 2017·Journal of Cellular Biochemistry·M S SyrkinaM A Rubtsov
Aug 5, 2000·International Journal of Cancer. Journal International Du Cancer·R J Quin, M A McGuckin
Jan 1, 2011·Cancers·Silvia Von Mensdorff-PouillyRené H M Verheijen
Apr 11, 2001·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·L P Nolan, M K Heatley
Aug 2, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Subhash C ChauhanSurinder K Batra
Jul 24, 2004·Critical Reviews in Clinical Laboratory Sciences·Stephan E BaldusFranz-Georg Hanisch
Jun 17, 2005·The American Journal of Surgical Pathology·Adriana Handra-LucaPierre Fouret
Aug 24, 2006·Expert Review of Anticancer Therapy·Xiu Feng HuPei Xiang Xing
Oct 13, 2012·Advances in Anatomic Pathology·Keith D Bohman, Adeboye O Osunkoya
Apr 5, 2001·Journal of the National Cancer Institute·S GuruswamyD M Benbrook
Jun 9, 2005·Critical Reviews in Clinical Laboratory Sciences·V ZieglschmidO Böcher
Nov 4, 2000·International Journal of Cancer. Journal International Du Cancer·S SatohM A Hollingsworth
Apr 5, 2001·Journal of the National Cancer Institute·U Veronesi, A Decensi
May 21, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kimberly FungBrian M Zeglis

❮ Previous
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