Expression of MUC5AC and MUC6 in invasive ductal carcinoma of the pancreas and relationship with prognosis

International Journal of Gastrointestinal Cancer
Ma JinfengMasaomi Mizutani

Abstract

MUC5AC and MUC6 are two major types of mucin that are abundantly present in the stomach; both of them form a gel of high viscosity that provides protection and lubrication. Expressions of MUC5AC and MUC6 are seen in pancreatic neoplasms, whereas the relationships between MUC5AC/MUC6 expression and clinicopathological factors and patient prognosis in invasive ductal carcinoma (IDC) of the pancreas have not been investigated. The aim of this study was to investigate MUC5AC and MUC6 expressions in IDC with special reference to clinicopathological factors and patient prognosis. Tissue samples were taken from 33 patients with IDC of the pancreas after radical surgical treatment. MUC5AC and MUC6 expressions were examined immunohistochemically. The expressions of MUC5AC and MUC6 were observed in the cytoplasm of the tumor cells. MUC5AC and MUC6 immunoreactivities in the cancer tissues were found in 21 (63.6%) and 15 (45.5%) of 33 cases of IDC of the pancreas, respectively. MUC5AC-negative expression was associated significantly with lymphatic invasion, venous invasion, lymph node metastasis, and MUC5AC-positive patients showed significant better survival than those MUC5AC-negative patients. MUC6 expression was significantly related to...Continue Reading

Citations

Aug 16, 2012·Hepatobiliary & Pancreatic Diseases International : HBPD INT·Yuichi TakanoToshio Morohoshi
Oct 27, 2011·Diagnostic Pathology·Tao WangYu F Cheng
Feb 8, 2018·Carcinogenesis·Shiv Ram KrishnSurinder K Batra
Nov 24, 2006·The American Journal of Surgical Pathology·Shinichi BanMichio Shimizu
Jul 7, 2005·Pathology Oncology Research : POR·László KopperJózsef Tímár
Nov 17, 2009·European Journal of Gastroenterology & Hepatology·Ying ChenMinghua Zhu
Jul 6, 2010·The British Journal of Surgery·M M AloysiusD N Lobo
Dec 12, 2013·Pancreas·Kathryn T ChenAnthony T Yeung
Aug 4, 2020·Journal of Cellular and Molecular Medicine·Shunda WangYupei Zhao
Sep 10, 2019·World Journal of Gastroenterology : WJG·Piera ZaccariGabriele Capurso

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Carcinoma, Ductal

Ductal carcinoma is a malignant neoplasm involving the ductal systems of any of a number of organs, such as the mammary glands, pancreas, prostate or lacrimal gland. Discover the latest research on ductal carcinoma here.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Related Papers

Journal of Hepato-biliary-pancreatic Sciences
Michiyo HigashiSuguru Yonezawa
Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
Carlo CapellaSocietà Italiana di Anatomia Patologica e Citopatologia Diagnostica/International Academy of Pathology, Italian division (SI
© 2022 Meta ULC. All rights reserved