Expression of mucin-1 in oral squamous cell carcinoma and normal oral mucosa: An immunohistochemical study

Journal of Oral and Maxillofacial Pathology : JOMFP
Arush ThakurManisha S Ahire

Abstract

Mucins are high-molecular-weight glycoproteins with a high O-linked carbohydrate content, which are synthesized by many secretory epithelial cells as membrane-bound and/or secreted products. Mucin-1 (MUC1) is a transmembrane mucin that protects and lubricates the mucous membranes of the human body and involves itself in various cellular functions such as growth, differentiation and signaling. An aberrant expression of MUC1 has been demonstrated in various human cancers. Many studies on MUC1 expression have been conducted on a variety of neoplastic lesions other than head-and-neck region. In this study, an attempt has been made to evaluate the MUC1 immunoexpression in oral squamous cell carcinoma (OSCC) and normal oral mucosa (NOM). This study aims to compare and correlate the immunoexpression of MUC1 in NOM and OSCC using immunohistochemical technique. Thirty patients of OSCC formed the study group and thirty patients were included in the control group (NOM). Formalin-fixed paraffin wax blocks were prepared from the tissue samples obtained. Immunohistochemistry (IHC) for MUC1 was performed, and the overall percentage of positive cells along with distribution and localization of immunoexpression was studied. Pearson's Chi-square...Continue Reading

Citations

Apr 22, 2020·Tissue Barriers·Grace C LinWinfried Neuhaus

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Methods Mentioned

BETA
biopsy
glycosylation

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Carcinoma, Squamous Cell

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