Expression of mucin 1 possessing a 3'-sulfated core1 in recurrent and metastatic breast cancer

International Journal of Cancer. Journal International Du Cancer
Hiroko IdeoKatsuko Yamashita

Abstract

Breast cancer is the most frequent cancer threatening the lives of women between the ages of 30 and 64. The cancer antigen 15-3 assay (CA15-3) has been widely used for the detection of breast cancer recurrence; however, its sensitivity and specificity are inadequate. We previously found that the breast cancer cell line YMBS secretes mucin 1 possessing 3'-sulfated core1 (3Score1-MUC1) into the medium. Therefore, we here evaluated whether 3Score1-MUC1 is secreted into the blood streams of breast cancer patients, and whether it can serve as an improved breast cancer marker. We developed a lectin-sandwich immunoassay, called Gal4/MUC1, using a 3'-sulfated core1-specific galectin-4 and a MUC1 monoclonal antibody. Using the Gal4/MUC1 assay method, we found that 3Score1-MUC1 was profoundly expressed in the blood streams of patients with recurrent and/or metastatic breast cancer. The positive ratio of the Gal4/MUC1 assay was higher than that of the CA15-3 assay in both primary (n = 240) and relapsed (n = 43) patients, especially in the latter of which the positive ratio of Gal4/MUC1 was 86%. whereas that of CA15-3 was 47%. Furthermore, serum Gal4/MUC1 levels could more sensitively reflect the recurrence of primary breast cancer patient...Continue Reading

References

Jun 18, 1974·Biochimica Et Biophysica Acta·Y UchidaT Sugimori
Aug 15, 1984·International Journal of Cancer. Journal International Du Cancer·J HilkensM van der Valk
Apr 22, 1999·Cancer Letters·H SönmezE Kökoglu
Nov 26, 1999·Biochimica Et Biophysica Acta·J Taylor-PapadimitriouM Dalziel
Dec 11, 2002·Journal of Biochemistry·Takashi OhkuraKatsuko Yamashita
Jul 27, 2004·American Journal of Clinical Pathology·Sean K LauPeiguo G Chu
Jun 5, 2007·The Journal of Biological Chemistry·Hiroko IdeoKatsuko Yamashita
Aug 11, 2007·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Tadahiro NozoeKosei Yasumoto
Nov 26, 2009·Nature Reviews. Cancer·Donald W Kufe
Jun 29, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A GoldhirschUNKNOWN Panel members

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Citations

Feb 20, 2016·Chemico-biological Interactions·Yonghwang Ha, Hyun-Kyung Choi
May 23, 2015·Drug Discoveries & Therapeutics·Yoshinori InagakiNorihiro Kokudo
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Feb 4, 2016·Proteomics·Parvez SyedUrpo Lamminmäki
Aug 29, 2016·Translational Oncology·Laura Jeffords MooreDidier Dréau
Mar 12, 2019·International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition·Inanc KarakoyunBanu Isbilen Basok
Feb 8, 2020·Clinical and Experimental Pharmacology & Physiology·Meixiong Cheng, Ling Liu
May 16, 2020·Cancer Biotherapy & Radiopharmaceuticals·Chunxin QinZhiyong Zhan
Jul 26, 2016·Molecular and Clinical Oncology·Umut Riza GündüzHakan Kocoglu
Jul 24, 2020·Sensors·Veronika GajdosovaJan Tkac
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Nov 10, 2017·Cellular and Molecular Life Sciences : CMLS·Cherylane Dubé-Delarosbil, Yves St-Pierre
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