Expression of multiple forms of brain cytochrome P450

Toxicology Letters
H W StrobelS Shen

Abstract

Multiple forms of cytochrome P450 (P450) in brain tissue have been demonstrated to be expressible in brain tissue using polymerase chain reaction (PCR) techniques, Northern blotting, hydroxylation activity assessment and cloning approaches. The antidepressant drug imipramine is metabolized by brain microsomes to multiple products by pathways inhibitable by quinidine, 7,8-benzoflavone, and ketoconazole, well-known inhibitors of P450-catalyzed reactions. Moreover, PCR studies revealed that a number of P450s are expressible in brain tissue and in glioma C6 cells. Quantitative PCR studies further demonstrated the response of many of these forms to induction in agreement with hydroxylation activity results.

References

Oct 10, 1977·Biochemical and Biophysical Research Communications·H A SasameS D Nelson
Nov 15, 1989·Cancer·D J Stralka, H W Strobel
Sep 30, 1987·Biochemical and Biophysical Research Communications·O SugitaA Kappas
Apr 17, 1995·Biochemical and Biophysical Research Communications·H Kawashima, H W Strobel
Mar 24, 1993·Molecular and Cellular Biochemistry·A V HodgsonH W Strobel
Nov 17, 1995·Journal of Chromatography. B, Biomedical Applications·D J Sequeira, H W Strobel

❮ Previous
Next ❯

Citations

Feb 10, 2000·Toxicology·K W Renton
Jul 1, 1999·Environmental Toxicology and Pharmacology·M DayalP K Seth
Oct 2, 2002·Journal of Neurochemistry·Sharon MiksysRachel F Tyndale
Jul 21, 2009·Toxicon : Official Journal of the International Society on Toxinology·J P Silva-NetoS L Costa
Jun 1, 2006·The Journal of Pharmacy and Pharmacology·Yasufumi ToriniwaNorimichi Nakahata
Mar 30, 2010·The European Journal of Neuroscience·Amandeep Mann, Rachel F Tyndale
Aug 24, 2006·Pharmacology & Therapeutics·Auinash Kalsotra, Henry W Strobel
Jan 15, 2008·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Vanesa G MartinezRobert O'Connor
Jun 1, 1997·Environmental Health Perspectives·O Pelkonen, H Raunio
Dec 18, 2001·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Tara E Nicholson, Kenneth W Renton
May 3, 2006·Molecular and Cellular Biochemistry·Sanjay YadavDevendra Parmar

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.