PMID: 7538485May 1, 1995Paper

Expression of muscle actins in diffuse mesotheliomas

Human Pathology
I T KungS M Wilson

Abstract

Ultrastructural examinations have shown myofibroblastoid differentiation in sarcomatoid/desmoplastic mesotheliomas, but immunohistochemical expression of muscle actins seldom has been documented. We examined 10 sarcomatoid, 12 epithelial, and five biphasic mesotheliomas immunohistochemically for the expression of muscle-specific actin (MSA) and smooth muscle actin (SMA) and compared it with that in 12 specimens of lung cancer. All of the sarcomatoid mesotheliomas were found to be positive for both MSA and SMA. The epithelial cells in nine epithelial and two biphasic mesotheliomas were positive for MSA, but SMA was only positive in one epithelial mesothelioma. Conversely, the lung cancers were negative for both MSA and SMA in the epithelial cells, except for one specimen that was weakly positive for MSA. The stromal cells in both the epithelial mesotheliomas and lung cancers were negative for cytokeratin but were positive for MSA and SMA, whereas the sarcomatoid and biphasic mesothelioma spindle cells were positive for all three antibodies. We concluded that sarcomatoid mesothelioma was positive for MSA and SMA, which is in support of its myofibroblastic differentiation, and that positivity for MSA in some epithelial mesotheliom...Continue Reading

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Citations

Jan 10, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Nelson G Ordóñez
Aug 30, 2012·Archives of Pathology & Laboratory Medicine·Aliya N HusainUNKNOWN International Mesothelioma Interest Group
Nov 24, 2004·Thoracic Surgery Clinics·Joseph M Corson
Jul 11, 2006·European Journal of Pharmacology·Masayoshi Kuwahara, Maki Kuwahara
Dec 3, 2014·Seminars in Diagnostic Pathology·Thomas M Ulbright, Robert H Young
Mar 4, 2006·Seminars in Diagnostic Pathology·Robert E Emerson, Thomas M Ulbright
Sep 21, 2001·Pathology International·H OkamuraT Ishihara
Dec 31, 1998·Histopathology·D Suárez Vilela, F M Izquierdo García
Apr 21, 2006·The American Journal of Surgical Pathology·Camilla E CominLuca Messerini
Jan 1, 1997·Pathology International·N SakumaT Ishihara
Sep 10, 2005·Expert Review of Molecular Diagnostics·Saul Suster, Cesar Moran
Jun 8, 2000·The American Journal of Surgical Pathology·N G Ordóñez
Mar 7, 2006·Ultrastructural Pathology·Josep Lloreta-Trull
Mar 6, 2008·Archives of Pathology & Laboratory Medicine·Armita BahramiJae Y Ro
Jul 9, 2008·Archives of Pathology & Laboratory Medicine·Leslie A Litzky

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