PMID: 8612627Mar 1, 1996Paper

Expression of myosin isoforms in denervated, cross-reinnervated, and electrically stimulated rabbit muscles

European Journal of Biochemistry
F BacouA d'Albis

Abstract

The expression of myosin heavy (MyHC) and light (MyLC) chain isoforms was analyzed after denervation and cross-reinnervation by a fast nerve of the slow-twitch Semimembranosus proprius (SMp) muscle, and after denervation and electrical stimulation at low frequency of the fast-twitch Semimembranous accessorius (SMa) muscle of the rabbit. The control SMp (100% type I fibers) expressed 100% type I MyHC and 100% slow-type (1S', 1S and 2S) MyLC isoforms. Five month denervation did not alter significantly the MyHC expression of the muscle, but induced the expression of a new type 1 MyLC corresponding most probably to an embryonic MyLC. Five-month cross-reinnervation of the SMp by the fast SMa nerve induced a large change of its fiber type properties. As shown by immunocytochemistry, almost all fibers were stained by fast myosin antibody, but a high proportion of them co-expressed slow myosin. This result was in agreement with biochemical data showing that fast MyHC and MyLC isoforms became predominant. The control SMa (nearly 100% type II fibers) expressed almost 100% type II MyHC (70% type IIb and 22% IIx/d) and 100% fast-type (1F, 2F and 3F) MyLC isoforms. Five month denervation of the SMa induced a shift in its MyHC, with 98% type...Continue Reading

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Citations

Jun 8, 2000·Muscle & Nerve·A A JamaliR L Lieber
Jun 22, 1999·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·A Jakubiec-PukaA Matusiak
Sep 15, 2010·The Journal of General Physiology·Mariana CasasEnrique Jaimovich
Sep 8, 2007·Tissue Engineering·Vikas DhawanDavid L Brown
Oct 12, 2010·The Journal of Bone and Joint Surgery. American Volume·Kasra RowshanRanjan Gupta
Jan 5, 2014·Skeletal Muscle·Patrick RobisonMartin F Schneider
Nov 17, 2007·Journal of Neuroscience Methods·Fulvio Urso-BaiardaAdriaan O Grobbelaar
Jun 11, 2015·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Xiaoxia QiuShicai Chen
Jan 27, 2015·Annual Review of Pathology·Kambez H BenamDonald E Ingber
Nov 24, 2004·Life Sciences·Tsuyoshi TakadaKichibee Otsuka
Nov 19, 2003·The European Journal of Neuroscience·Magda SimonGiorgio Terenghi
Jan 16, 2007·American Journal of Physiology. Cell Physiology·Z AshleyJ C Jarvis
Oct 24, 2008·American Journal of Physiology. Cell Physiology·O AgbulutA Ferry
Mar 31, 1998·Developmental Dynamics : an Official Publication of the American Association of Anatomists·G McKoyG Goldspink
Jul 13, 2004·Journal of Applied Physiology·Julia M GigerKenneth M Baldwin
Jan 21, 2000·Journal of Applied Physiology·B CormeryP F Gardiner

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