Expression of Myostatin in Intrauterine Growth Restriction and Preeclampsia Complicated Pregnancies and Alterations to Cytokine Production by First-Trimester Placental Explants Following Myostatin Treatment

Reproductive Sciences
H N PeirisMurray D Mitchell

Abstract

Preeclampsia (PE) and intrauterine growth restriction (IUGR) are major obstetric health problems. Higher levels of T-helper (Th) 1 (proinflammatory) cytokines have been observed in pregnancies complicated with PE and IUGR; this is in contrast to the predominant Th2 (anti-inflammatory) cytokine environment found in uncomplicated pregnancies. Myostatin is best known as a negative regulator of muscle development and reportedly has a role in fat deposition, glucose metabolism, and cytokine modulation (outside the placenta). Myostatin concentrations in plasma and protein expression in placental tissue are significantly higher in women with PE. Expression of myostatin in IUGR and PE-IUGR and the effect of this protein on the cytokine production from the placenta is unknown. In the current study, significant differences were identified in the expression of myostatin in pregnancies complicated with IUGR, PE, and PE with IUGR. Furthermore, cytokine production by first-trimester placental tissues was altered following myostatin treatment.

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Citations

Jan 23, 2021·Trends in Endocrinology and Metabolism : TEM·Yan LiPeter C K Leung
Jul 25, 2021·International Journal of Molecular Sciences·Chelsie B SteinhauserMichael Carey Satterfield

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Methods Mentioned

BETA
cesarean section
enzyme-linked immunosorbent assay
Assay
X-ray
ELISA

Software Mentioned

Bio
Plex Manager
GraphPad Prism
Quantity One

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