Expression of MYSM1 is associated with tumor progression in colorectal cancer

PloS One
Yongmin LiBinbin Cui

Abstract

Colorectal cancer, the third most common cancer in both men and women, has gradually increased in recent years. MYSM1has been investigated as a regulator of hematopoiesis and lymphocyte development in human. It has been reported that some tumor-related genes were modulated by MYSM1. However, its exact role in cancer development remains unclear. Herein, we aimed to examine the expression level of MYSM1 in tumor tissues and its correlation with clinicopathology and survivals of patients with colorectal cancer (CRC).MYSM1expressions in tumor specimens resected from 123 CRC patients were detected by immunochemistry and Western blot analysis. The results showed that MYSM1 was significantly highly expressed in carcinoma tissues compared with adjacent normal mucosa tissues (P<0.05). Correlation analyses by Pearson's chi-square test demonstrated that MYSM1 in tumors was positively correlated with tumor status (pathological assessment of the primary tumor (pT, P<0.001), regional lymph nodes (pN, P = 0.013), distant metastasis (pM, P<0.001)) and clinic stage (P<0.001); Whereas, MYSM1 was not associated with tumor size of CRC patients and was positively associated with tumor differentiation grade (P = 0.015). Patients with positiveMYSM1ex...Continue Reading

References

Aug 19, 2003·Seminars in Surgical Oncology·Brian O'Sullivan, Jatin Shah
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May 7, 2016·International Journal of Molecular Sciences·Dianbao ZhangXining Pang

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Citations

May 30, 2020·International Journal of Molecular Sciences·Carsten KroegerMartina Vanessa Gatzka
Apr 30, 2020·International Journal of Molecular Sciences·Amanda FioreAnastasia Nijnik

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Methods Mentioned

BETA
histone acetylation
transfection
ubiquitination
deubiquitination

Software Mentioned

Ambion
SPSS Statistics

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