Expression of NAD(P)H oxidase subunits and their contribution to cardiovascular damage in aldosterone/salt-induced hypertensive rat.

Journal of Korean Medical Science
Young Mee ParkJeong Bae Park

Abstract

NAD(P)H oxidase plays an important role in hypertension and its complication in aldosterone-salt rat. We questioned whether NAD(P)H oxidase subunit expression and activity are modulated by aldosterone and whether this is associated with target-organ damage. Rats were infused with aldosterone (0.75 microg/hr/day) for 6 weeks and were given 0.9% NaCl+/-losartan (30 mg/kg/day), spironolactone (200 mg/kg/day), and apocynin (1.5 mM/L). Aldosterone-salt hypertension was prevented completely by spironolactone and modestly by losartan and apocynin. Aldosterone increased aortic NAD(P)H oxidase activity by 34% and spironolactone and losartan inhibited the activity. Aortic expression of the subunits p47(phox), gp91(phox), and p22(phox) increased in aldosterone-infused rats by 5.5, 4.7, and 3.2-fold, respectively, which was decreased completely by spironolactone and partially by losartan and apocynin. Therefore, the increased expression of NAD(P)H oxidase may contribute to cardiovascular damage in aldosterone-salt hypertension through the increased expression of each subunit.

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Citations

Nov 17, 2009·Arteriosclerosis, Thrombosis, and Vascular Biology·Bernard Lassègue, Kathy K Griendling
May 15, 2012·Circulation Research·Bernard LassègueKathy K Griendling
Sep 21, 2011·Molecular and Cellular Endocrinology·Morag J Young, Amanda J Rickard
Feb 18, 2011·British Journal of Pharmacology·K WinglerH H H W Schmidt
Jul 23, 2011·Free Radical Biology & Medicine·Sergey Dikalov
May 23, 2012·Free Radical Biology & Medicine·Nina Queisser, Nicole Schupp
Jun 21, 2012·Biochemical and Biophysical Research Communications·Melanie MuehlfelderTheo Pelzer
Jul 29, 2009·Brain Research·Kimberly A KellyJason D Huber
Aug 2, 2016·Journal of Atherosclerosis and Thrombosis·Yasuyoshi KigawaAkira Miyazaki
Oct 20, 2018·Antioxidants & Redox Signaling·Rhian M TouyzAugusto C Montezano
Jul 23, 2011·British Journal of Pharmacology·Daliao XiaoLubo Zhang
Nov 13, 2014·Hormone Molecular Biology and Clinical Investigation·Sarah Elisabeth Louise EvenAurelie Nguyen Dinh Cat

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Methods Mentioned

BETA
PCR
transgenic
transfection

Software Mentioned

SPSS
IITT

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