PMID: 8957740Oct 1, 1996Paper

Expression of natriuretic peptide receptors in human adipose and other tissues

Journal of Endocrinological Investigation
R SarzaniA Rappelli

Abstract

To characterize natriuretic peptide receptor (NPr) gene expression in human tissues, we cloned portions of the cDNAs codifying for NPr with guanylyl cyclase activity (NPr-A and NPr-B) and without guanylyl cyclase activity (NPr-C). Total RNA was extracted from samples taken at surgery from normal human tissues. NPr-A and NPr-B cDNAs obtained from lung as well as NPr-C cDNA obtained from renal cortex were cloned, characterized, and used for comparative Northern analysis. NPr-A mRNA (approximately 4 kb) was most abundant in adipose tissue (8 patients) independently on the site of sampling, whereas it was approximately 2.5-fold and 5-fold less abundant, respectively, in kidney (either renal cortex or papilla from 3 patients) and adrenal (4 patients), known target tissues of natriuretic peptides. NPr-C mRNAs (approximately 7.7 and 6.8 kb) had a similar tissue distribution but the highest levels were found in renal tissue and only very low expression levels were found in adrenals (approximately 20-fold lower than renal cortex). The ratio of NPrA versus NPr-C mRNA levels were highest in adrenal and lowest in renal tissue. NPr-B mRNA (approximately 4 kb), which encodes the receptor for the C-type natriuretic peptide, had a different an...Continue Reading

References

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Citations

May 14, 2014·High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension·Riccardo SarzaniMassimiliano Fedecostante
May 15, 2010·International Journal of Pediatrics·L B MänhardtR Buchhorn
Jul 20, 2012·Journal of General Internal Medicine·Eric D MorrellAsher A Tulsky
Mar 5, 2013·Obesity Surgery·Niclas AbrahamssonF Anders Karlsson
Aug 7, 2002·International Journal of Cardiology·Paul R Kalra, Stelios Tigas
Jul 8, 2010·Circulation Journal : Official Journal of the Japanese Circulation Society·Kensaku HigashiHirohito Tsubouchi
Jun 22, 2010·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Speranza RubattuMassimo Volpe
Oct 1, 2008·Expert Opinion on Medical Diagnostics·Kevin JiangAlan S Maisel
Apr 7, 2010·Diabetes Research and Clinical Practice·Takako SugisawaYasunao Yoshimasa
Jul 15, 2009·Archivos de bronconeumología·Felipe Villar AlvarezJavier de Miguel Díez
Feb 22, 2008·The American Journal of Cardiology·Antoni Bayes-GenisJames L Januzzi
Oct 12, 2007·Regulatory Peptides·Søren J NielsenJens F Rehfeld
Mar 11, 2016·Reviews in Endocrine & Metabolic Disorders·Jens Jordan, Andreas L Birkenfeld
Feb 26, 2004·Obesity Research·Riccardo SarzaniAlessandro Rappelli
Jul 1, 2009·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·A M R BeleigoliA L P Ribeiro
Oct 4, 2008·Congestive Heart Failure·Ken McDonaldRoberto Valle
Sep 2, 2008·European Journal of Heart Failure·Alan MaiselEugene Braunwald
Dec 17, 2008·Journal of Hospital Medicine : an Official Publication of the Society of Hospital Medicine·Alpesh Amin
Jan 3, 2006·European Journal of Heart Failure·Antonio MuscariMarco Zoli
Jul 5, 2012·Clinical Cardiology·Selim R KrimJames A de Lemos
Oct 10, 2013·Geriatrics & Gerontology International·Ji-Hung WangBang-Gee Hsu
Aug 28, 2004·The Medical Clinics of North America·Satish KenchaiahRamachandran S Vasan
May 2, 2014·Pharmacology & Therapeutics·Nina SchlueterAndreas L Birkenfeld
Nov 10, 2010·The American Journal of Cardiology·Annabel Chen-TournouxThomas J Wang
May 25, 2010·The American Journal of Cardiology·Nita Chainani-WuDean Ornish
Mar 24, 2005·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Noriko AoiKoichi Matsumoto
Jun 4, 2015·Biochimie·Marine Coué, Cedric Moro
Mar 3, 2015·Journal of Cardiac Failure·Ruth M Masterson CreberBarbara Riegel
Mar 26, 2015·The Journal of Endocrinology·Margo P EmontJun Wu
Feb 21, 2006·Journal of the American College of Cardiology·Roland van KimmenadeYigal Pinto
May 4, 2004·Journal of the American College of Cardiology·Mandeep R MehraEdward D Frohlich

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