Expression of natriuretic peptides in rat Müller cells

Neuroscience Letters
Li-Hui CaoXiong-Li Yang

Abstract

Natriuretic peptides (NPs) have been shown to modulate neuronal activities. By immunohistochemistry and confocal microscopy, we examined expression of atrial NP (ANP), brain NP (BNP) and C-type NP (CNP) in rat retina. Our results showed that these peptides were differentially expressed in the neural retina. While strong ANP-, BNP- and CNP-immunoreactivity (IR) was clearly seen in the outer and inner plexiform layers and on numerous neurons in the inner nuclear layer, BNP- and CNP-, but not ANP-IR, was present in some ganglion cells. Furthermore, ANP, BNP and CNP were expressed in Müller cells with distinct profiles, as shown by double labeling of NPs and vimentin. Labeling for BNP was rather strong in the main trunks, major processes, but hardly detectable in the endfeet. The expression profile for ANP was similar, but with a much lower level. On the contrary, the endfeet and major processes in the inner retina were strongly CNP-positive, with the main trunks and other major processes in the outer retina much less labeled. These results raise a possibility that NPs, when released from Müller cells, may perform layer dependent functions.

References

Jan 1, 1992·Cold Spring Harbor Symposia on Quantitative Biology·T D ChrismanD L Garbers
Feb 5, 1999·European Journal of Pharmacology·R Fernández-DurangoR Bernal
Dec 16, 2000·The Journal of Comparative Neurology·K R Zahs, T Wu
Oct 23, 2001·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·J C McKenzieR M Klein

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Citations

Mar 23, 2010·Brain Research Bulletin·Guo-Zhong XuXiong-Li Yang
Jan 25, 2008·Progress in Neurobiology·Li-Hui Cao, Xiong-Li Yang

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