Expression of Natural Cytotoxicity Receptors on and Intracellular Cytokine Production by NK Cells in Women with Gestational Diabetes Mellitus

American Journal of Reproductive Immunology : AJRI
Hitomi ChibaHideki Mizunuma

Abstract

To determine the role of peripheral blood NK (pNK) cells in putative etiology of gestational diabetes, the expression of surface markers on pNK cells and the percentage of cytokine-producing pNK cells in women at 12 weeks of pregnancy with gestational diabetes mellitus (GDM) were studied. Multicolor flow cytometry was used to analyze the expression of NK cell surface receptors (CD16, NKp46, and NKp30) and intracellular cytokines (IFN-γ, TNF-α, TGF-β, and VEGF) in pNK cells (CD56(dim) and CD56(bright) ) at 12 weeks of pregnancy with GDM (n = 7) and non-GDM (n = 28). CD56(bright) /CD16(-) NK and CD56(bright) /NKp46(+) NK cell percentage were significantly lower in GDM women than that in non-GDM women. IFN-γ- and TNF-α-producing CD56(+) cells, respectively, were significantly high, while TGF-β- and VEGF-producing CD56(+) cells and CD56(bright) cells, respectively, were significantly low in GDM women. Women with GDM possibly have abnormal NK cell function for the expression of surface receptors and cytokine production.

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Citations

Jun 14, 2016·Journal of Immunology Research·Cristiane de Castro Pernet HaraIracema de Mattos Paranhos Calderon
Jan 18, 2017·Mucosal Immunology·A M Felker, B A Croy
Dec 19, 2019·Scandinavian Journal of Immunology·Thiago P B De LucciaSilvia Daher
Sep 9, 2020·American Journal of Reproductive Immunology : AJRI·Atsushi FukuiHiroaki Shibahara
May 26, 2017·Diabetes & Metabolism Journal·Beatriz Dal Santo Francisco Bonamichi, Jongsoon Lee
Jan 10, 2018·American Journal of Reproductive Immunology : AJRI·Thalita Frutuoso LoboSilvia Daher
May 11, 2018·The Journal of Endocrinology·Patrik ŠimjákMartin Haluzík
Sep 17, 2019·The Science of the Total Environment·Huanhuan ZhangCunrui Huang
Apr 13, 2021·Food Science & Nutrition·Yan YangJingjing Zhang
May 1, 2021·International Journal of Molecular Sciences·Colm J McElwainCathal M McCarthy

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