Expression of nestin in dermatofibrosarcoma protuberans in comparison to dermatofibroma

The Journal of Dermatology
Toru MoriYutaka Narisawa

Abstract

Making a differential diagnosis to distinguish dermatofibrosarcoma protuberans (DFSP) from dermatofibroma (DF) is occasionally difficult. In those instances, CD34 and factor XIIIa have been used as valuable differential markers. The histogenesis of DFSP, however, remains uncertain and controversial, although it is generally thought to be a neuromesenchymal neoplasm. Nestin is an intermediate filament protein that was first observed in neuroectodermal stem cells. We investigated the expression of nestin in order to distinguish between DFSP and DF in combination with the use of conventional markers, CD34 and factor XIIIa. The nestin expression was investigated in tissue specimens from 16 DFSP cases and 30 DF cases. The expression of other differential markers such as CD34, factor XIIIa, CD163 and CD10 was also observed in these samples. Fifteen (94%) of 16 cases of DFSP showed the expression of nestin, whereas only four (13%) of 30 cases of DF showed the expression of nestin. Most of the DFSP cases showed a diffuse positive reaction in more than half of the tumor cells. In contrast, DF cases with nestin expression showed a partial positive reaction. Nestin is considered to be a useful and additional marker in combination with CD3...Continue Reading

References

May 1, 1990·The Journal of Comparative Neurology·B FriedmanS Hockfield
Jan 1, 1995·The American Journal of Surgical Pathology·P R CohenA I Farhood
Oct 1, 1994·The American Journal of Dermatopathology·P R CohenA I Farhood
Oct 1, 1993·The American Journal of Surgical Pathology·S W Weiss, B J Nickoloff
Oct 1, 1993·The American Journal of Dermatopathology·P Abenoza, T Lillemoe
Feb 1, 1993·The Journal of Investigative Dermatology·A E AllanM Peacocke
May 1, 1997·Differentiation; Research in Biological Diversity·K FröjdmanJ E Eriksson
Mar 20, 1998·Pediatric Research·M KobayashiT Sejersen
Feb 28, 2002·Journal of the American Academy of Dermatology·Bernard CribierEdouard Grosshans
Apr 27, 2002·Histochemistry and Cell Biology·Eugenio BertelliLuciano Fonzi
Aug 24, 2002·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Maarit Sarlomo-RikalaMarkku Miettinen
Aug 9, 2003·Proceedings of the National Academy of Sciences of the United States of America·Lingna LiRobert M Hoffman
Nov 5, 2004·Cellular and Molecular Life Sciences : CMLS·C WieseA M Wobus
May 9, 2006·Experimental Neurology·Karl J L FernandesFreda D Miller
Dec 5, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Walter M KleinSteven R Tahan
Feb 16, 2007·Pathology International·Satoko ShimadaPeter B Illei
Apr 24, 2007·Journal of Cutaneous Pathology·Svetlana BrychtovaJaroslav Hirnak

❮ Previous
Next ❯

Citations

Jun 8, 2010·World Journal of Surgical Oncology·Dimitrios M DragoumisAris P Tsiftsoglou
Oct 24, 2012·The Kaohsiung Journal of Medical Sciences·Yi-Ting ChenChee-Yin Chai
Jan 19, 2013·Seminars in Diagnostic Pathology·Beatriz LlombartOnofre Sanmartín
Jan 31, 2012·Actas dermo-sifiliográficas·C Serra-GuillénO Sanmartín
Mar 23, 2011·Dermatologic Clinics·Hillary Johnson-Jahangir, Désirée Ratner
Mar 27, 2010·Journal of the European Academy of Dermatology and Venereology : JEADV·N MisagoY Narisawa
Jan 22, 2011·Journal of Cutaneous Pathology·Klaus SellheyerRajiv M Patel
Apr 16, 2011·Journal of the European Academy of Dermatology and Venereology : JEADV·J LiH Chen
Jul 16, 2010·Journal of the European Academy of Dermatology and Venereology : JEADV·O Abbas, J Bhawan
Dec 17, 2009·Journal of Cutaneous Pathology·Klaus Sellheyer, Dieter Krahl
Dec 31, 2014·Archives of Pathology & Laboratory Medicine·Tammie Ferringer
Oct 29, 2013·The American Journal of Dermatopathology·Kelly L WestPuja K Puri
Apr 1, 2017·Applied Immunohistochemistry & Molecular Morphology : AIMM·Joon Seon SongKyung-Ja Cho
Feb 19, 2013·Oncology Reports·Michiko AkiyamaSeiji Kawana
Jan 15, 2021·Journal of Immunoassay & Immunochemistry·Nadia KoukiSlim Haouet
Aug 31, 2019·Dermatologic Clinics·Aubrey AllenOmar P Sangüeza

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.