Expression of neural BC200 RNA in human tumours

The Journal of Pathology
W ChenH Tiedge

Abstract

BC200 RNA is a 200-nucleotide-long non-messenger RNA that is selectively expressed in the primate nervous system, where it has been identified in somatodendritic domains of a subset of neurons. BC200 RNA is not normally expressed in non-neuronal somatic cells; it has been shown, however, to be expressed in germ cells and in cultured immortal cell lines of various non-neural origins. In order to investigate whether the neuron-specific expression of BC200 RNA is also deregulated during tumourigenesis in non-neural human tissues, 80 different tumour specimens, representing 19 different tumour types, were screened for the presence of the RNA. BC200 RNA was expressed in carcinomas of the breast, cervix, oesophagus, lung, ovary, parotid, and tongue, but not in corresponding normal tissues. BC200 RNA was not detectable in bladder, colon, kidney, or liver carcinoma tissues examined in this study. These results demonstrate that BC200 expression is deregulated under certain neoplastic conditions. The expression of BC200 RNA in non-neural tumours may indicate a functional interrelationship with induction and/or progression of such tumours.

References

Mar 25, 1991·Proceedings of the National Academy of Sciences of the United States of America·H TiedgeJ Brosius
May 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·T M DeChiara, J Brosius
Jun 1, 1987·Molecular and Cellular Biology·R D McKinnonJ G Sutcliffe
Sep 1, 1987·Molecular and Cellular Biology·J B Watson, J G Sutcliffe
Sep 1, 1986·Molecular and Cellular Biology·M F CareyN R Cozzarelli
Feb 1, 1988·Molecular and Cellular Biology·J Tower, B Sollner-Webb
Nov 8, 1984·Nature·E Ullu, C Tschudi
Dec 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·J A Martignetti, J Brosius
Jan 1, 1993·Annual Review of Neuroscience·G Mandel, D McKinnon
Oct 1, 1995·Current Opinion in Neurobiology·C J Schoenherr, D J Anderson
Jul 1, 1996·DNA and Cell Biology·J G ChengJ Brosius
Feb 1, 1997·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·W ChenH Tiedge

❮ Previous
Next ❯

Citations

Dec 23, 2003·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R J White
Feb 15, 2014·Arthritis Research & Therapy·Pia MoinzadehVoon H Ong
Jun 8, 2007·Proceedings of the National Academy of Sciences of the United States of America·El MusHenri Tiedge
Jun 3, 2014·Respiratory Research·Mark M PerryKian Fan Chung
Nov 1, 2000·Proceedings of the National Academy of Sciences of the United States of America·A G WinterR J White
Apr 25, 2012·Journal of Toxicology and Environmental Health. Part a·Petra KieselHans Zischler
Aug 16, 2014·Nucleic Acids Research·Kotb AbdelmohsenMyriam Gorospe
Nov 30, 2000·Nucleic Acids Research·C AlemánP L Deininger
Apr 9, 2008·Molecular and Cellular Biology·Annette WoiwodeDeborah L Johnson
May 6, 2008·The Journal of Biological Chemistry·Sandra A S JohnsonDeborah L Johnson
Nov 7, 2008·Journal of Virology·Hancheng GuanRobert P Ricciardi
Mar 10, 2009·Nucleic Acids Research·Barbara P MelloHelena Brentani
Sep 29, 2009·Nucleic Acids Research·Mariana Pavon-EternodTao Pan
Oct 12, 2010·Nucleic Acids Research·Andrew M ParrottMichael B Mathews
Mar 10, 2012·Journal of Mammary Gland Biology and Neoplasia·Amy N ShoreJeffrey M Rosen
May 23, 2012·Journal of Translational Medicine·Jiri SanaOndrej Slaby
Oct 12, 2012·Carcinogenesis·Qingsong ZhangShuping Zhong
Sep 17, 2013·International Journal of Molecular Sciences·Jing LiChangning Liu
Sep 22, 2012·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Peng Qi, Xiang Du
Dec 21, 2012·Nucleic Acids Research·Mariana Pavon-EternodJonathan W Yewdell
Nov 7, 2008·Nature Reviews. Cancer·Lynne Marshall, Robert J White
Aug 15, 2014·International Journal of Molecular Sciences·Maria SmolleJohannes Haybaeck
Jul 5, 2015·Biochimica Et Biophysica Acta·Jiyoung KimMyriam Gorospe
Mar 5, 2016·Pflügers Archiv : European journal of physiology·Márta SzéllLajos Kemény
Nov 5, 2008·Trends in Genetics : TIG·Robert J White
Feb 20, 2008·Seminars in Cancer Biology·Márta SzéllLajos Kemény
Sep 4, 2015·Wiley Interdisciplinary Reviews. RNA·Kotb Abdelmohsen, Myriam Gorospe
Mar 17, 2009·Journal of Cellular Biochemistry·Callie Pollock, Sui Huang
Feb 10, 2012·Medicinal Research Reviews·Xiaolei LiWeidong Han
Jun 18, 2015·Molecular and Cellular Therapies·Roshan FatimaSatyanarayana Mr Rao
Apr 15, 2011·Molecular Cancer·Ewan A GibbWan L Lam
Apr 27, 2011·Molecular Cancer·Stephanie Cabarcas, Laura Schramm
Aug 23, 2005·Gene·Fabrício F Costa
Aug 2, 2012·Genetics Research International·Katey S S EnfieldWan L Lam
Sep 13, 2014·Briefings in Functional Genomics·Vakul MohantySarath Chandra Janga
Jun 13, 2015·BMC Genomics·Carsten KülheimWilliam J Foley
May 29, 2015·RNA Biology·Zhen XingLiuqing Yang
Jul 18, 2008·Journal of Experimental & Clinical Cancer Research : CR·Massimo MallardoOscar Fernando D'Urso
Jun 6, 2012·RNA Biology·Tony Gutschner, Sven Diederichs

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bladder Carcinoma In Situ

Bladder Carcinoma In Situ is a superficial bladder cancer that occurs on the surface layer of the bladder. Discover the latest research on this precancerous condition in this feed.

Related Papers

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
W ChenH Tiedge
© 2021 Meta ULC. All rights reserved