Expression of neural cell adhesion molecules (polysialylated form of neural cell adhesion molecule and L1-cell adhesion molecule) on resected small cell lung cancer specimens: in relation to proliferation state

Journal of Surgical Oncology
R MiyaharaH Wada

Abstract

Alteration of homotypic cell-cell adhesion has been suggested to play an important role in tumor progression. The present study examined the relationship between neural cell adhesion molecules and state of proliferation of small cell lung cancer (SCLC) cells. Seventeen surgically resected specimens of SCLC were immunohistochemically examined, by using monoclonal antibodies against neural cell adhesion molecule (NCAM) and its polysialic acid side chains, and L1 cell adhesion molecule (L1-CAM). Ki-67 labeling indices were also determined immunohistochemically. All patients were positive for L1-CAM. Fifteen patients (88.2%) were positive for NCAM. Among the fifteen patients, nine (60.0%) were positive for NCAM PSA side chain. The probability of survival of the NCAM without PSA side chain group was significantly higher than that of the NCAM with PSA side chain group (log-rank test; P = 0.500). The expression of NCAM with PSA side chains might be a prognostic factor and NCAM a marker for SCLC. L1-CAM may be synthesized independent of state of proliferation of individual tumor cell and may affect clinical feature of SCLC.

References

Mar 1, 1992·The Journal of Cell Biology·P YangU Rutishauser
May 1, 1992·European Journal of Immunology·A KowitzP Altevogt
Jan 1, 1991·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R E KibbelaarN Van Zandwijk
Jul 16, 1990·FEBS Letters·M C Aletsee-UfrechtM Gratzl
Jan 1, 1990·The Journal of Cell Biology·G KadmonM Schachner
Apr 15, 1989·International Journal of Cancer. Journal International Du Cancer·D LinnemannE Bock
Sep 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·S Hoffman, G M Edelman
Jan 1, 1994·International Journal of Cancer. Supplement = Journal International Du Cancer. Supplement·J A LedermannG Pelosi
Feb 1, 1996·The Journal of Cell Biology·A M MontgomeryR A Reisfeld
Mar 6, 1997·Biochemical and Biophysical Research Communications·A DuczmalP Altevogt
Feb 12, 1998·Cell Structure and Function·M KatayamaK Ishii
Feb 12, 1998·Pediatric Research·S GlüerR Gerardy-Schahn
Oct 20, 1998·The American Journal of Surgical Pathology·S LantuejoulE Brambilla

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Citations

Jan 10, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Jussuf T KaifiJakob R Izbicki
Jul 10, 2009·Proceedings of the National Academy of Sciences of the United States of America·Penelope M DrakeCarolyn R Bertozzi
Dec 21, 2011·The Journal of Biological Chemistry·Joseph L Zapater, Karen J Colley
Jun 22, 2013·Journal of Biochemistry·Chihiro Sato, Ken Kitajima
Jun 20, 2013·Journal of the National Cancer Institute·Alain G ZeimetMina Fogel
Oct 12, 2011·Molecular Cancer·Verena TischlerAlex Soltermann
Oct 6, 2007·Annals of Surgical Oncology·Robin WachowiakJakob R Izbicki
Apr 24, 2009·Acta neurochirurgica·Athanasios K PetridisHubertus Maximilian Mehdorn
Jun 27, 2015·International Journal of Cancer. Journal International Du Cancer·Peter AltevogtMina Fogel
Nov 17, 2009·Cancer Investigation·Nektaria MakriliaKostas Syrigos
Oct 4, 2011·Vaccine·Jamie Heimburg-MolinaroKate Rittenhouse-Olson
Jan 5, 2011·The Journal of Surgical Research·Tamina RawnaqJussuf T Kaifi
Mar 4, 2008·Urologic Oncology·Mark Nogueira, Hyung L Kim
Feb 27, 2004·Journal of Cutaneous Pathology·Ryan T MottMichael B Morgan
May 30, 2013·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Paul J SmithRachel J Errington
Nov 7, 2014·Critical Reviews in Biochemistry and Molecular Biology·Karen J ColleyChihiro Sato
Jun 9, 2012·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Marco BlessmannJakob R Izbicki
Sep 18, 2007·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Jussuf T KaifiJakob R Izbicki
Feb 13, 2007·International Journal of Cancer. Journal International Du Cancer·Mostafa JarahianFrank Momburg
Mar 2, 2010·Molecular Carcinogenesis·Paola B CampodónicoLaura B Todaro
Apr 10, 2009·The Biochemical Journal·Lissa R HerronFrank J Gunn-Moore
Jan 28, 2006·World Journal of Gastroenterology : WJG·Jussuf T KaifiJakob R Izbicki

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