Expression of NeuroD in the mouse taste buds.

Cell and Tissue Research
Yuko SuzukiNobuko Obara

Abstract

NeuroD, a basic helix-loop-helix transcription factor, has been shown to play a role in the differentiation of neurons, olfactory cells, and neuroendocrine tissues. Since the taste buds have characteristics of typical paraneurons, we examined the expression of NeuroD in the taste buds of mice. By RT-PCR analysis, NeuroD mRNA was found to be expressed in the epithelium of circumvallate papillae-containing taste buds, but not in the lingual epithelium lacking them. NeuroD immunoreactivity was detected in a subset of taste bud cells in the circumvallate, foliate, and fungiform papillae and in the soft palate. NeuroD-expressing cells had a spindle-like shape, first appeared at postnatal day 3, and increased in number during postnatal development. After bisection of the glossopharyngeal nerves, NeuroD-expressing cells decreased in number at day 4 and disappeared from the trench wall of the circumvallate papillae by day 14. A few NeuroD-expressing taste buds reappeared at postoperative day 28. Denervation and regeneration experiments showed that expression of NeuroD in the taste buds was dependent upon gustatory innervation. Double immunolabeling with gustducin or with neural cell adhesion molecule (NCAM) showed that NeuroD-expressin...Continue Reading

Citations

Jul 30, 2010·Journal of Molecular Histology·Yuko SuzukiKiyoshi Kawakami
Oct 12, 2005·Journal of Neurocytology·Bruce Oakley, Martin Witt
Oct 18, 2007·BMC Neuroscience·Robin F Krimm
Feb 9, 2007·Archives of Histology and Cytology·Hirohito MiuraShuitsu Harada
Sep 3, 2011·Zoological Science·Miyako NishiyamaYasuhiro Tomooka
Sep 23, 2006·FEBS Letters·Rafael Ortíz-AlvaradoFrancisco Bolaños-Jiménez
Sep 29, 2006·The European Journal of Neuroscience·Marcus KrügerThomas Braun

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