Expression of neuronal mRNAs in Alzheimer type degeneration of the nervous system

The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques
A W Clark, I M Parhad

Abstract

There is extensive evidence for decrements of gene expression in AD, at several levels in the process. There is also evidence for increments of expression of some genes. Message for the amyloid precursor protein (APP), for example, is elevated in surviving neurons of certain subcortical populations in AD. We evaluated expression of message for APP as well as for certain neuronal and glial cytoskeletal proteins in the cortex of six cases of AD. Neuronal mRNAs, including that for APP, were significantly decreased when compared with control cortex, whereas the glial mRNA was increased. We have projected studies to determine the evolution of these mRNA decrements in Alzheimer-type degeneration. The rationale for these studies and preliminary findings are discussed.

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Citations

Nov 1, 1991·Psychological Medicine·P J HarrisonR C Pearson
Mar 1, 1991·The International Journal of Neuroscience·J A Jesberger, J S Richardson
Apr 16, 2003·Journal of Neurochemistry·Matthew R HyndPeter R Dodd
Jun 3, 2006·Analytical and Bioanalytical Chemistry·Jillian R A NewtonMalcolm R Clench
Jun 12, 2012·The Journal of Biological Chemistry·Loredana SpoerriRoberto Cappai
Jan 1, 1992·Brain Research. Molecular Brain Research·C W PerrettR M Marchbanks

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