PMID: 8961299Nov 15, 1996Paper

Expression of neuronal nitric oxide synthase in spinal motoneurons in aged rats

Neuroscience Letters
K Kanda

Abstract

We investigated the expression of nitric oxide synthase (NOS) in motoneurons of aged rats by the nicotinamide adenine dinucleotide phosphate (NADPH)-diaphorase (NADPH-d) reaction. The number of NADPH-d positive neurons (i.e. presumed motoneurons) in the motor nucleus at L4-L6 level of the spinal cord was 0.0 +/- 0.0 for 13- to 15-month-old rats, 2.2 +/- 0.8 for 24-month-old rats, and 7.9 +/- 5.4 for 29- to 32-month-old rats. These NADPH-d positive neurons were multipolar in shape and the soma cross-sectional area was 820 +/- 245 mu2 (n = 56; range, 359-1460 mu2) which was similar to the value for alpha-motoneurons. The results indicate that nitric oxide (NO) may be produced by a few motoneurons in the aged rat spinal cord and may lead these neurons to eventual death.

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Citations

May 3, 2003·Neuroscience Research·Alicia VillenaIgnacio Pérez de Vargas
Apr 1, 1999·Nitric Oxide : Biology and Chemistry·J P BoisselU Förstermann
Jul 26, 2012·Oxidative Medicine and Cellular Longevity·Junyang JungYoungbuhm Huh
Nov 9, 2002·Microscopy Research and Technique·Kenro Kanda
May 16, 1998·Biochemical and Biophysical Research Communications·C CapanniC M Caldarera

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