PMID: 9258870Jul 14, 1997Paper

Expression of neuropeptides and nitric oxide synthase in neurones innervating the inflamed rat urinary bladder

Journal of the Autonomic Nervous System
P Callsen-Cencic, S Mense

Abstract

Micturition reflexes become hyperexcitable with the development of a cystitis. In the present study the question is addressed, whether alterations in the expression of neuropeptides and nitric oxide synthase (NOS) in the neuronal pathways to the bladder may be involved in the hyperexcitability. Primary sensory neurones in the dorsal root ganglia (DRG) L1, L2, L6 and S1 as well as postganglionic efferent neurones in the major pelvic ganglia (MPG) that innervate the rat urinary bladder were labeled with retrogradely transported Fast Blue (FB). Immunocytochemical techniques were used to determine alterations in the expression of calcitonin gene-related peptide (CGRP), substance P (SP), galanin (GAL) and NOS in these neurones following mustard oil-induced inflammation of the urinary bladder. Instillation of 2.5% mustard oil into the bladder led to a massive leukocyte infiltration of the vesical tissues, partial damage of the mucosal layer and a marked hyperreflexia of the detrusor muscle. 48 h after induction of the cystitis the proportion of FB-labeled bladder afferent neurones that expressed CGRP and SP were significantly increased in both the rostral lumbar DRGs (L1, L2) and the lumbosacral DRGs (L6, S1) (CGRP, +15-38%; SP, +47-...Continue Reading

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Citations

Jun 29, 2001·Journal of Chemical Neuroanatomy·A JiménezM A Peinado
May 30, 2001·The International Journal of Biochemistry & Cell Biology·S Harrison, P Geppetti
Nov 19, 2008·Molecular Interventions·David R Robinson, G F Gebhart
Jun 6, 2003·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Yojiro UkaiNoboru Toda
Nov 23, 2010·Neuropeptides·Roland Lang, Barbara Kofler
Mar 5, 2005·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Ubirajara BarrosoMiguel Srougi
Jun 17, 1998·The Journal of Urology·P Callsen-Cencic, S Mense
Jun 14, 2018·American Journal of Physiology. Renal Physiology·Luke GrundyDavid Grundy
Jun 19, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·U C KoppT Hökfelt
Mar 7, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·Allen C MyersBradley J Undem
Jul 22, 2018·Scientific Reports·Daniel S C ButlerCatharina Svanborg
Nov 24, 2020·PloS One·Michal ZaleckiAmelia Franke-Radowiecka
Aug 24, 2010·Autonomic Neuroscience : Basic & Clinical·Phillip Jobling

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