Expression of neurotrophin receptors by retinoinvasive uveal melanoma

Melanoma Research
Tatyana MilmanP T Finger

Abstract

Retinoinvasive uveal melanoma demonstrates prominent diffuse retinal and optic nerve invasion, with little or no involvement of the adjacent choroid. Prior studies have advanced hypotheses on the potential role of molecular and cellular interactions in the pathogenesis of retinoinvasiveness and neuroinvasiveness, but the precise molecular events are not known. Here, we investigate the role of neutrotrophic factors in the pathogenesis of retinoinvasive uveal melanoma. The records of three ophthalmic pathology departments (The New York Eye and Ear Infirmary, Wills Eye Institute, and University of California San Francisco) were searched to identify all cases of retinoinvasive uveal melanoma, yielding four eyes (all previously irradiated). Eight eyes with nonretinoinvasive melanomas (four irradiated and four nonirradiated) were randomly selected as controls. All enucleated eyes were examined histopathologically and immunohistochemically for the expression of neurotrophic factor receptors [Pan-Trk, p75 neurotrophin receptor (p75(NTR) and ciliary neurotrophic factor receptor-α]. Histopathologic features were similar in both retinoinvasive and control melanomas with regard to choroidal tumor location and size, neovascular glaucoma, an...Continue Reading

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Jan 19, 2018·Ocular Oncology and Pathology·John P GorhamHans E Grossniklaus
Feb 6, 2020·Vestnik oftalmologii·A F BrovkinaI V Musatkina
Oct 4, 2020·Retina·Vishal RavalArun Singh
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Jan 15, 2021·Ocular Oncology and Pathology·Aaron JamisonVikas Chadha

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