PMID: 8584261Nov 10, 1995Paper

Expression of neurotrophins and their receptors in sciatic nerve of experimentally diabetic rats

Neuroscience Letters
A Rodríguez-PeñaF Requejo

Abstract

The levels of neurotrophins and their receptor mRNAs were measured in rat sciatic nerve, after 6 or 12 weeks of streptozotocin-induced diabetes. Expression of neurotrophin-3 (NT-3) and neurotrophin-4 (NT-4) was decreased by 50 and 29%, respectively, compared with age-matched controls after 12 weeks of diabetes. Expression of brain-derived neurotrophic factor (BDNF) was not detected. In addition, diabetes induced a reduction in the expression levels of the neurotrophin receptors: trkB mRNA decreased by 50% after 6 weeks of diabetes, but returned to control levels after 12 weeks; meanwhile the trkC and p75LNGFR transcripts were reduced by 20% of control at both times studied. trkA expression was below detection limits. Thus, these data suggest that a reduction in neurotrophin and neurotrophin receptors could contribute to the development and maintenance of diabetic neuropathy.

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Mar 20, 2003·Current Diabetes Reports·Nigel A Calcutt
Jul 23, 2002·Brain Research·Qing-Gui Xu, Douglas W Zochodne
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