PMID: 10213469Apr 23, 1999

Expression of neurotrophins in the adult spinal cord in vivo

Journal of Neuroscience Research
Cheryl F DreyfusI B Black

Abstract

Potential roles of trophins in the normal and injured spinal cord are largely undefined. However, a number of recent studies suggest that adult spinal cord expresses neurotrophin receptors and responds to the neurotrophins, brain-derived neurotrophic factor (BDNF) and neurotrophin 3 (NT3), particularly after injury. The data indicate that trophins may enhance regrowth after damage and may represent a new therapeutic approach to injury. Neurotrophins are reportedly present in the spinal cord, but the cellular localization is unknown. This information is critical to begin delineating mechanisms of actions. To approach this problem, we examined whether spinal cord glia express BDNF and NT3 in vivo and have begun to define cellular distribution. Specific antibodies directed against the neurotrophins were utilized to visualize neurotrophin protein. Initial studies indicated that small cells in the white matter of adult rat spinal cord express BDNF and NT3. Large neurotrophin-positive neurons were also identified in the ventral cord. To identify the neurotrophin-positive cells, co-localization studies were performed utilizing neurotrophin polyclonal antisera together with monoclonal antibodies directed against the astrocyte marker, g...Continue Reading

References

Feb 13, 2001·Biochemical and Biophysical Research Communications·I MizutaS Kuno
Apr 23, 2014·Molecular Neurobiology·Mette RichnerChristian Bjerggaard Vaegter
Nov 20, 2004·PLoS Biology·Bariş GençReha S Erzurumlu
Jun 3, 2008·Cellular and Molecular Life Sciences : CMLS·A NairS D Miller
Feb 28, 2002·The European Journal of Neuroscience·V L Arvanian, L M Mendell
Oct 20, 2010·Expert Opinion on Biological Therapy·Tanya J Wyatt, Hans S Keirstead
Jan 27, 2016·Journal of the Neurological Sciences·Mauricio F Farez, Jorge Correale
Dec 14, 2011·The Journal of Pain : Official Journal of the American Pain Society·Ken-Ichiro HayashidaJames C Eisenach
Jul 19, 2008·Respiratory Physiology & Neurobiology·Francis J Golder
Jul 27, 2007·Pharmacology & Therapeutics·Synthia H Mellon
Oct 31, 2006·Frontiers in Neuroendocrinology·Farida Sohrabji, Danielle K Lewis
Jun 21, 2005·Journal of Cellular and Molecular Medicine·T Magnus, M S Rao
Jun 9, 2014·Neuron·Alicia Guemez-GamboaNicholas C Spitzer
Mar 19, 2016·Experimental Neurology·Hülya KıraySusan C Barnett
May 19, 2006·Expert Opinion on Therapeutic Targets·Simone Di Giovanni
Dec 18, 2013·Translational Neuroscience·Angela LanciottiElena Ambrosini
Sep 23, 2003·Brain Research·Zhe YingFernando Gómez-Pinilla
Dec 18, 2001·The Journal of Comparative Neurology·A JosephsonC Spenger
Dec 22, 1999·The Journal of Comparative Neurology·Charles R BuckTimothy C Cope
Mar 30, 2004·Journal of Neuroscience Research·Hai WuCheryl F Dreyfus
Dec 21, 2004·Journal of Molecular Histology·Catherine P RileyCharles R Buck
Jul 20, 2006·International Anesthesiology Clinics·Elizabeth Vernon PittsRita J Balice-Gordon
Nov 30, 2006·Journal of Neuroscience Research·M C OsborneD R Sengelaub
Mar 5, 2017·Histochemistry and Cell Biology·Martina KuglerBarbara M Braunger

Citations

Dec 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·J FrisénM Risling
Jan 1, 1994·Brain Research Bulletin·J P Schwartz, N Nishiyama
Dec 20, 1994·Nihon Naibunpi Gakkai zasshi·K Yoshida, H Oshima
Sep 13, 1994·Proceedings of the National Academy of Sciences of the United States of America·S ByravanA T Campagnoni
Feb 10, 1998·The Journal of Comparative Neurology·M ShibayamaA Tessler
Mar 28, 1998·The European Journal of Neuroscience·L NovikovaJ O Kellerth

Related Concepts

Glial Fibrillary Acidic Protein
Transcription, Genetic
Neurons
Astrocytes
Bdnf
Immunocytochemistry
Neuroglia
Brain-Derived Neurotrophic Factor
Neurite Outgrowth Factors
Spinal Cord

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