PMID: 9184664Jun 1, 1997Paper

Expression of NF2-encoded merlin and related ERM family proteins in the human central nervous system

Journal of Neuropathology and Experimental Neurology
A O Stemmer-RachamimovV Ramesh

Abstract

Germline mutations of the neurofibromatosis 2 (NF2) gene are associated with an increased incidence of gliomas and glial harmartomas, suggesting a role for the NF2-encoded protein, merlin, in glial growth control. Using monoclonal and polyclonal anti-merlin antibodies for Western blotting and immunohistochemistry, we evaluated the cellular pattern of merlin expression in the normal human central nervous system (CNS), reactive gliosis; and NF2-associated glial hamartomas. In the normal CNS, merlin is widely expressed in coarse cytoplasmic granules in both glia and neurons, with less pronounced expression in other cells. Merlin is also expressed in reactive astrocytes and in the astrocytes of NF2-associated glial hamartomas. In reactive astrocytes, however, merlin is also present at the cell membrane and in cellular processes, suggesting redistribution of the protein in activated cells. Merlin is structurally related to ezrin, radixin and moesin, which are also expressed in the CNS, as demonstrated by Western blotting. The pattern of merlin expression, however, is distinct from that of ezrin, which has been previously described, and that of moesin, in which immunohistochemistry with an anti-moesin antibody showed expression in en...Continue Reading

Citations

Sep 2, 2003·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Takahiro TomitaShunro Endo
Apr 29, 2005·The Journal of Molecular Diagnostics : JMD·Rebecca A BetenskyDavid N Louis
May 21, 2004·Nature Reviews. Neuroscience·Vijaya Ramesh
Oct 14, 2000·Annual Review of Cell and Developmental Biology·A BretscherD Reczek
Feb 17, 2010·Neuro-oncology·Fabiana C MoralesMaria-Magdalena Georgescu
Dec 14, 2011·Acta Neuropathologica·Steven L Carroll
Feb 1, 2003·Journal of Neurochemistry·Natalia Denisenko-NehrbassJean-Antoine Girault
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