PMID: 7525687Sep 1, 1994Paper

Expression of nitric oxide synthase immunoreactivity by interstitial cells of the canine proximal colon

Journal of the Autonomic Nervous System
C XueK M Sanders

Abstract

A subpopulation of interstitial cells (ICs) are interposed between nerve terminals and smooth muscle cells in the gastrointestinal tract and may participate in neuromuscular transmission. These cells appear to be targets for NO released from enteric inhibitory nerves and respond to exogenous NO with: (i) an elevation in cGMP levels; (ii) an increase in intracellular Ca2+; (iii) and release of a diffusible substance that has tentatively been identified as NO. For the latter to be possible, ICs must express a constitutive isoform of NOS. This study characterized the expression of NOS-like immunoreactivity (NOS-LI) in ICs of the canine colon using 3 antibodies raised against the 2 known constitutive forms of NOS (i.e., neural (nNOS) and endothelial (eNOS) isoforms). Antibodies raised against cNOS and an antibody raised against rat cerebellar nNOS labeled ICs along the submucosal surface of the circular muscle layer (IC-SM), along the surface of septa that separate the circular muscle into fiber bundles (IC-SM), and in the myenteric region between the circular and longitudinal muscle layers (IC-MY). Another antibody raised against rat cerebellar nNOS failed to label ICs. Cultured IC-SM also expressed NOS-LI, suggesting that this fe...Continue Reading

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Citations

Oct 1, 1995·The Histochemical Journal·J S PollockM Nakane
Jan 1, 1996·Histochemistry and Cell Biology·S TorihashiK M Sanders
Dec 5, 1995·Journal of the Autonomic Nervous System·C W ShuttleworthI L Buxton
Dec 23, 1998·Journal of the Autonomic Nervous System·R HaggerD Kumar
Mar 20, 1998·Comparative Biochemistry and Physiology. Part A, Physiology·G E Boeckxstaens, P A Pelckmans
Jun 20, 1997·Neuroscience Letters·P Matini, M S Faussone-Pellegrini
Sep 12, 2002·Nitric Oxide : Biology and Chemistry·Huige LiUlrich Förstermann
Mar 14, 2001·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·C Olsson, S Holmgren
Aug 27, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Jie NiOlivier Devuyst
Mar 29, 2014·Naunyn-Schmiedeberg's Archives of Pharmacology·Pawan Kumar ShahiJae Yeoul Jun
Oct 16, 1999·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·K M SandersS M Ward
Apr 12, 2001·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·S M MillerJ H Szurszewski
Aug 14, 2009·Fundamental & Clinical Pharmacology·Nilce Mitiko Matsuda, Steven M Miller
Sep 26, 2003·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·X-Y WangJ D Huizinga
Jul 22, 2014·European Journal of Pharmacology·Antonella AmatoFlavia Mulè
Oct 9, 2008·European Journal of Pharmacology·Smain AmiraFlavia Mulè
Aug 24, 2005·Progress in Neurobiology·F X GuixF J Muñoz
Oct 17, 1998·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·M Onoda, H Inano
Dec 22, 1999·Microscopy Research and Technique·G Farrugia, J H Szurszewski
Feb 24, 2018·Scientific Reports·Natalia V NizyaevaGennadiy T Sukhikh
Nov 23, 2005·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·César FurlánEnri Borda
May 25, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·M C BaccariD Bani
Jul 18, 2008·American Journal of Physiology. Renal Physiology·Angeles García-PascualDomingo Triguero
Oct 13, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·Sushil K Sarna
Dec 22, 1999·Microscopy Research and Technique·M S Faussone-Pellegrini, L Thuneberg
Dec 22, 1999·Microscopy Research and Technique·M G Vannucchi
Feb 10, 1999·The American Journal of Physiology·M JiménezE E Daniel
May 9, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Kuldip S Banwait, Satish Rattan
Feb 2, 2019·Investigative Ophthalmology & Visual Science·David RamosJesús Ruberte
Jan 9, 2001·The Anatomical Record·S M Ward, K M Sanders

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