PMID: 9545560May 28, 1998Paper

Expression of NK-2 class homeobox gene Nkx2-6 in foregut endoderm and heart

Mechanisms of Development
Christine BibenRichard P Harvey

Abstract

NK-2 class homeobox genes are candidate patterning and lineage regulators in diverse organisms. We report here the embryonic expression pattern of murine member, Nkx2-6. In keeping with its vertebrate relatives, Nkx2-6 was transcribed in ventrolateral embryonic structures. Expression was first detected at E8.0 in endodermal walls of the foregut pocket, tissue destined to become pharyngeal floor. From E8.0-10.5, transcripts were concentrated in pharyngeal pouches and juxtaposed arch ectoderm and mesoderm, as well as in more caudal gut segments. Expression was also seen at opposite poles of the developing heart from E8-8.5 in posterior myocardial progenitors, then sinus venosa and dorsal pericardium, and from E9.5 in outflow tract myocardium.

References

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Citations

Jan 30, 2010·Development Genes and Evolution·Karl R WottonKatharine E Lewis
Jun 1, 2005·Pharmacology & Therapeutics·Hiroshi Akazawa, Issei Komuro
Jul 16, 2003·Cold Spring Harbor Symposia on Quantitative Biology·R P HarveyE Kirk
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Mar 13, 2014·Developmental Biology·Lu ZhangChen-Leng Cai
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Nov 9, 2014·Pediatric Cardiology·Juan WangYi-Qing Yang
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Oct 17, 2014·International Journal of Molecular Medicine·Jun WangYi-Qing Yang

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