Expression of NK cluster genes in the onychophoran Euperipatoides rowelli : implications for the evolution of NK family genes in nephrozoans

EvoDevo
Sandra TreffkornGeorg Mayer

Abstract

Understanding the evolution and development of morphological traits of the last common bilaterian ancestor is a major goal of the evo-devo discipline. The reconstruction of this "urbilaterian" is mainly based on comparative studies of common molecular patterning mechanisms in recent model organisms. The NK homeobox genes are key players in many of these molecular pathways, including processes regulating mesoderm, heart and neural development. Shared features seen in the expression patterns of NK genes have been used to determine the ancestral bilaterian characters. However, the commonly used model organisms provide only a limited view on the evolution of these molecular pathways. To further investigate the ancestral roles of NK cluster genes, we analyzed their expression patterns in the onychophoran Euperipatoides rowelli. We identified nine transcripts of NK cluster genes in E. rowelli, including single copies of NK1, NK3, NK4, NK5, Msx, Lbx and Tlx, and two copies of NK6. All of these genes except for NK6.1 and NK6.2 are expressed in different mesodermal organs and tissues in embryos of E. rowelli, including the anlagen of somatic musculature and the heart. Furthermore, we found distinct expression patterns of NK3, NK5, NK6, ...Continue Reading

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Citations

Dec 12, 2019·Royal Society Open Science·Ivo de Sena OliveiraGeorg Mayer
Apr 25, 2019·International Journal of Molecular Sciences·Xitan HouZhifeng Zhang
Jun 2, 2020·Frontiers in Endocrinology·Christine MartinGeorg Mayer

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Datasets Mentioned

BETA
MH036363

Methods Mentioned

BETA
PCR

Software Mentioned

segemehl
Adobe Photoshop
tBLASTx
RAxML
Adobe
BLASTn
MAFFT
Adobe Illustrator CS
Pthreads
ZEN

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