Expression of NLRP3 inflammasome in leprosy indicates immune evasion of Mycobacterium leprae

Memórias do Instituto Oswaldo Cruz
Ana Luisa Gomes MendesMarcelo Antônio Pascoal-Xavier

Abstract

Leprosy is an infectious-contagious disease caused by Mycobacterium leprae that remain endemic in 105 countries. This neglected disease has a wide range of clinical and histopathological manifestations that are related to the host inflammatory and immune responses. More recently, the inflammasome has assumed a relevant role in the inflammatory response against microbiological agents. However, the involvement of inflammasome in leprosy remains poorly understood. The aim is to associate biomarkers of inflammasome with the different immunopathological forms of leprosy. We performed an observational, cross-sectional, and comparative study of the immunophenotypic expression of inflammasome-associated proteins in immunopathological forms of leprosy of 99 skin lesion samples by immunohistochemistry. The intensity and percentage of NLRP3, Caspase-1, Caspases-4/5, interleukin-1β and interleukin-18 immunoreactivities in the inflammatory infiltrate of skin biopsies were evaluated. Strong expression of NLRP3 and inflammatory Caspases-4/5 were observed in lepromatous leprosy (lepromatous pole). In addition, were observed low expression of caspase-1, interleukin-1β, and interleukin-18 in tuberculoid and lepromatous leprosy. The interpolar or...Continue Reading

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Methods Mentioned

BETA
biopsies

Software Mentioned

MINITAB
EXCEL
R
VGAM

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