Expression of nm23-H1 and COX-2 in thyroid papillary carcinoma and microcarcinoma

Oncology Letters
Marija Milkovic PerisaSven Seiwerth

Abstract

The expression of non-metastatic expressed/non-metastatic 23 nucleoside diphosphate kinase 1 (nm23-H1) and cyclooxygenase 2 (COX-2) proteins in thyroid carcinoma have been analysed in a number of previous studies, but this requires further study. The current study focused on the expression levels of nm23-H1 and COX-2 in 130 human thyroid papillary carcinoma (PTC) tissues. Of the 130 PTC tissues, 55 were classified as microcarcinoma and may provide information on the development of the specific characteristics of this tumour type. Routine histopathological examination and immunohistochemical detection of nm23-H1 and COX-2 expression was performed on 130 PTC tissues from patients treated in the Clinical Hospital for Tumours (Zagreb, Croatia) between January 2000 and December 2007. The stain intensity of nm23-H1 and COX-2 proteins was compared with the characteristics of the patients and the tumour. The highest overall expression rate of nm23-H1 and COX-2 was 90 and 67.6%, respectively, and the joint expression of these proteins was statistically significant. The median expression level of nm23-H1 was significantly increased in the classical and follicular histological group of the PTC tissues compared with tissues from other hist...Continue Reading

References

Sep 1, 1993·World Journal of Surgery·D R FarleyS Khosla
Aug 1, 1993·British Journal of Cancer·M ZouN R Farid
May 23, 1998·Annual Review of Pharmacology and Toxicology·J R VaneR M Botting
Jul 15, 1998·Oncology·A YamaguchiG Nakagawara
Nov 4, 2000·Journal of the National Cancer Institute·B A YoshidaC W Rinker-Schaeffer
Jan 5, 2002·Journal of Bioenergetics and Biomembranes·M L LacombeD O Lambeth
Jan 15, 2002·The Journal of Clinical Endocrinology and Metabolism·Michelle C SpechtThomas J Fahey
Mar 13, 2002·The Laryngoscope·Anthony J CornettaJay L Rothstein
Mar 8, 2003·International Journal of Gastrointestinal Cancer·Young-Eun JooSei-Jong Kim
Apr 26, 2003·Histopathology·Y ItoA Miyauchi
Jul 10, 2003·Journal of Bioenergetics and Biomembranes·Taoufik OuatasPatricia S Steeg
Jan 14, 2004·The Korean Journal of Internal Medicine·Sang Jin KimMyung Hi Yoo
May 14, 2004·Histopathology·P SiironenC Haglund
Jun 11, 2005·Virchows Archiv : an International Journal of Pathology·Miguel García-GonzálezJosé Cameselle-Teijeiro
Mar 8, 2008·Annals of Surgical Oncology·Antonio ToniatoMariarosa Pelizzo
Aug 16, 2008·Endocrine Journal·Yasuhiro Ito, Akira Miyauchi
Nov 11, 2008·Pathology, Research and Practice·H Moradi TabrizS M Tavangar
May 6, 2009·Molecular and Cellular Biochemistry·Jong Heun LeeChristine E Horak
Feb 22, 2011·Experimental and Molecular Pathology·Havva ErdemSare Sipal
Apr 27, 2013·Thyroid : Official Journal of the American Thyroid Association·Stefania ScarpinoLuigi Ruco
Aug 9, 2013·Indian Journal of Pathology & Microbiology·Karone ShahebrahimiAliasghar Keshavarz

❮ Previous
Next ❯

Citations

Oct 23, 2018·Oncology Letters·Wenzhong WeiXiao Liang
Dec 18, 2020·International Journal of Molecular Sciences·Sandeep Kumar ParvathareddyKhawla S Al-Kuraya

❮ Previous
Next ❯

Methods Mentioned

BETA
dissection

Software Mentioned

SPSS
SPSS Statistics

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved