PMID: 9194030May 1, 1997Paper

Expression of nm23 protein in pulmonary adenocarcinomas: inverse 1orrelation to tumor progression

Lung Cancer : Journal of the International Association for the Study of Lung Cancer
Y KawakuboT Kameya

Abstract

Immunohistochemical assessment was made of nm23 protein expression in pulmonary adenocarcinoma. Of the 147 adenocarcinomas 67% (99/147) were weakly and 33% (48/147) strongly positive for nm23 protein. nm23 protein expression in primary tumors was shown to correlate inversely with advancing pathologic stage and the degree of metastasis in regional lymph nodes (P < 0.05). The staining of tumors without nodal metastasis was more intense than with nodal metastasis (P < 0.02). Nodal metastasis was seen in 37% (55/147) cases examined. The immunoreactivity to nm23 protein in tumor cells of nodal metastasis was essentially the same as in those of primary tumors (P < 0.01). Significant correlation between patient prognosis and immunoreactivity for nm23 in primary tumors (P < 0.05) was demonstrated. But none could be found between immunoreactivity and other parameters such as histologic grading, distant metastasis, tumor size or disease-free survival. Neither was there any significant correlation between pathologic parameters examined and the expression of nm23 in any histologic subtype. Multivariate analysis using Cox's proportional hazards regression model with five variables indicated nm23 and lymph node metastasis to contribute to ov...Continue Reading

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Citations

Apr 24, 2009·Molecular and Cellular Biochemistry·Jean-Claude MarshallPatricia S Steeg
May 8, 2004·Annals of Diagnostic Pathology·Viktor N GoncharukJeffrey S Ross
Jul 14, 1999·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·M TomitaT Onitsuka
Apr 28, 2011·Nature Reviews. Clinical Oncology·Alexander N ShoushtariCarrie W Rinker-Schaeffer
Mar 16, 2002·Journal of Clinical Pathology·Alastair N J GrahamJ A McGuigan
Aug 14, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Patricia S SteegKathy D Miller
Apr 10, 2007·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Hao ZhangXueyuan Xiao
May 9, 2002·The Annals of Thoracic Surgery·Hiromichi KatakuraHiromi Wada
Oct 11, 2017·Laboratory Investigation; a Journal of Technical Methods and Pathology·Choon-Yee Tan, Christina L Chang
May 15, 2003·Clinical Breast Cancer·Patricia S SteegMassimiliano Salerno

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