Expression of non-muscle myosin heavy chain in rat heart after immunosuppressive treatment

International Immunopharmacology
Rita RezzaniRossella Bianchi

Abstract

Myosins constitute a large family of molecular motors, hydrolyzing ATP and producing cellular movement. To date, a large number of novel isoforms have been found in muscle and non-muscle cells. Among non-muscle myosins, non-muscle myosin heavy chain (NMHC) II-A and II-B have been well characterized. An additional member of NMHC II-B, with a molecular weight of 220 kDa, was recently identified in bovine skeletal muscle. NMHC II-B proteins, in particular, have been suggested to be a useful early molecular marker for the detection of pathological conditions during acute or chronic organ rejection in which fibrotic changes occur. Since it is known that treatment with cyclosporine A (CsA), an immunosuppressive drug successfully used for preventing organ rejection and autoimmune diseases, is often associated with several side effects (hypertension and nephrotoxicity), the aims of this study were: (1) to demonstrate the homology of the new NMHC protein (220 kDa) in other mammalian species, such as Wistar rats; (2) to evaluate, by morphological and immunohistochemical studies, the possible changes induced by CsA treatment in NMHC protein (220 kDa) cellular localization and/or in its expression levels in myocardial tissue. First of all,...Continue Reading

References

Nov 14, 1997·Proceedings of the National Academy of Sciences of the United States of America·A N TullioR S Adelstein
May 21, 1999·Biochemical and Biophysical Research Communications·M TakahashiA Yamagishi
Mar 21, 2000·Biochimica Et Biophysica Acta·J R Sellers
Mar 10, 2001·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·C LionneJ Kendrick-Jones
Jan 10, 2002·The Journal of Cell Biology·Daniel H SchottAnthony Bretscher
Mar 29, 2002·British Journal of Haematology·Alessandro PecciCarlo L Balduini
Mar 19, 2003·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Elena PompiliLorenzo Fumagalli
Sep 10, 2004·Progress in Histochemistry and Cytochemistry·Rita Rezzani

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.