Expression of notch family proteins in placentas from patients with early-onset severe preeclampsia

Reproductive Sciences
Wei-Xiu ZhaoJian-Hua Lin

Abstract

This study is aimed to identify the expression of Notch family proteins in placentas from patients with early-onset severe preeclampsia. The expression of Notch family proteins in placentas was investigated by immunohistochemistry, Western blotting, and real-time reverse transcription-polymerase chain reaction (RT-PCR). The profile of distribution of all Notch family proteins in placentas from patients with early-onset severe preeclampsia is similar to that in normal placentas. All Notch family proteins are expressed in placental trophoblasts. Moreover, Notch1 and Jagged1 (Jag1) are detected in placental endothelial cells. Real-time RT-PCR showed that messenger RNA levels of Notch2 and Delta-like4 (Dll4) in placentas from patients with early-onset severe preeclampsia are lower than that of normal placentas. Western blotting showed a significant increase in Notch3 expression and a significant decrease in Notch2 expression in placentas from patients with early-onset severe preeclampsia relative to those in normal placentas. The results suggest that Notch2 and Notch3 may play some roles in the pathogenesis of preeclampsia.

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Citations

Aug 9, 2017·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Yu-Qi LiXun Gong
Nov 2, 2019·Cells·Xiang-Qun Hu, Lubo Zhang
Oct 24, 2019·Journal of Cellular Physiology·Yuan YuanYan Cai

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Methods Mentioned

BETA
cesarean section
immunoprecipitation assay

Software Mentioned

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