Abstract
The NADPH oxidase (NOX) family is overexpressed in many cancers and is associated with cancer cell proliferation and metastasis; however, little is known about the role of the NOX family in colorectal cancer (CRC). To identify the expression of the NOX family in CRC and to investigate the relationship between the expression of NOXs with the prognosis of the patients. In the TCGA data portal, mRNA expression data were obtained from 41 normal samples and 458 CRC samples to analyze mRNA expression and gene alteration. We compared the survival differences according to the degree of expression of NOX family in CRC patients and performed Gene Set Enrichment Analysis (GSEA). The mRNA expression of NOX1, 3, 4, and DUOX1, 2 was significantly increased in the colorectal adenocarcinoma. Especially, the higher T and N stage, the more NOX4 expression was significantly increased. Survival analyses showed that NOX4 and NOX5 were associated with poor prognosis; however, NOX1 and DUOX2 were significantly associated with better prognosis. In the results of GSEA of CRC patients, the NOX4 gene was significantly associated with Angiogenesis, EMT and notch signaling. The NOX family is overexpressed in CRC and is associated with the prognosis of the ...Continue Reading
References
Sep 17, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D G Kirsch, M B Kastan
Oct 7, 2004·Journal of the National Cancer Institute·Jessica B O'ConnellClifford Y Ko
Jun 2, 2005·Cellular Signalling·Kendra D MartynUlla G Knaus
Oct 19, 2005·Cancer Research·Jodi K Maranchie, Ye Zhan
Feb 21, 2006·Journal of Theoretical Biology·Steven R McDougallMark A J Chaplain
Apr 19, 2006·Cancer Research·Astrid LièvrePierre Laurent-Puig
Apr 6, 2007·Endocrine Reviews·Victoria BolósJosé Luis de la Pompa
Aug 21, 2007·Thyroid : Official Journal of the American Thyroid Association·Melania PulcranoMartin Schlumberger
Feb 19, 2008·Cancer Research·Sylvia LuxenUlla G Knaus
Mar 15, 2008·Cancer Research·Binod KumarHari K Koul
Oct 11, 2008·Journal of Hepatology·Irene Carmona-CuencaIsabel Fabregat
Oct 17, 2008·Cancer Research·Astrid C HaugenMinoru Koi
Jul 25, 2009·Free Radical Biology & Medicine·David I Brown, Kathy K Griendling
Nov 6, 2010·Cell and Tissue Research·Adrian Manea
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
Jun 1, 2012·Cellular and Molecular Life Sciences : CMLS·Sebastian AltenhöferHarald H H W Schmidt
Oct 11, 2012·PloS One·Patricia SanchoIsabel Fabregat
May 22, 2013·Biochemical Pharmacology·Biao ZhangXun Hu
Mar 13, 2014·Journal of Mathematical Biology·F SpillH M Byrne
Sep 24, 2014·Current Medicinal Chemistry·M TomasettiJ Neuzil
Feb 6, 2015·CA: a Cancer Journal for Clinicians·Lindsey A TorreAhmedin Jemal
Mar 13, 2015·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Kyu-Won JungKang Hyun Lee
Apr 29, 2015·Oncotarget·Hyun Jung KimKong-Joo Lee
Apr 20, 2017·Oncotarget·Xiao-Lu LinZhi-Zheng Ge
Citations
May 28, 2019·Journal of Cellular Physiology·Alireza AnvarniaDariush Shanehbandi
Mar 10, 2020·Bioscience Reports·Mao-Lin WanQing Wu
Aug 15, 2020·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Joo Young KimHojung Lee
May 27, 2020·Genetics and Molecular Biology·Caroline Coelho de Faria, Rodrigo Soares Fortunato
Feb 6, 2020·Antioxidants & Redox Signaling·Mariam M KonatéJames H Doroshow
Dec 29, 2020·Anatomy & Cell Biology·Choong Heon RyuDae Young Hur
Dec 10, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Qiaowei FanHulun Li
Nov 15, 2020·Cancers·Eva ParisiMaria Alba Sorolla
May 24, 2020·Redox Biology·Chi-Chen FanWei-Chao Chang
Jun 3, 2021·Journal of Personalized Medicine·Constantin BusuiocIoana Berindan-Neagoe