Expression of obesity-related adipokine genes during fasting in a naturally obese marine mammal

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Jane I KhudyakovDaniel E Crocker

Abstract

Northern elephant seals (Mirounga angustirostris) are exceptional among fasting-adapted animals in coupling prolonged fasting with energetically costly activities, relying on oxidation of fat stores accrued during foraging to power metabolic demands of reproduction and molting. We hypothesized that high rates of energy expenditure, insulin resistance, and immune responses to colonial breeding in fasting seals are mediated by adipokines, or signaling molecules secreted by adipose tissue that are associated with obesity and inflammation in humans. We measured mRNA expression of 10 adipokine genes in blubber tissue of adult female elephant seals sampled early and late during their lactation and molting fasts and correlated gene expression with adiposity and circulating levels of corticosteroid and immune markers. Expression of adiponectin (ADIPOQ) and its receptor ADIPOR2, leptin receptor (LEPR), resistin (RETN), retinol binding protein 4 (RBP4), and visfatin/nicotinamide phosphoribosyltransferase (NAMPT) was increased, whereas that of fat mass and obesity-associated protein (FTO) was decreased in late-fasted compared with early-fasted groups. Abundance of adipokine transcripts that increased in late fasting was negatively associa...Continue Reading

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Citations

Mar 31, 2021·General and Comparative Endocrinology·Caroline L RzucidloDaniel E Crocker
Jul 15, 2021·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Julia María Torres-VelardeJosé Pablo Vázquez-Medina

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Methods Mentioned

BETA
PCR
biopsy
biopsies
electrophoresis

Software Mentioned

BLAST
R
RStudio
Excel
Hmisc
BLASTX
PrimerQuest Tool
corrplot

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