Expression of occludin, a tight-junction-associated protein, in human lung carcinomas

Virchows Archiv : an International Journal of Pathology
Hirotoshi TobiokaNorimasa Sawada

Abstract

Occludin is a tight-junction-associated transmembrane protein, and previous observations suggested that occludin might play a crucial role in the formation and maintenance of organized tubular structures. Based on these observations, we explored the possible role of occludin immunostaining in the diagnosis of lung carcinomas. A total of 68 lung carcinomas and surrounding normal lung tissues were studied. A formalin-fixed, paraffin-embedded section from each tumor was stained with a new anti-occludin monoclonal antibody raised in our laboratory. In normal lung tissues, the anti-occludin antibody strongly stained the apicoluminal borders of the bronchial/bronchiolar epithelia and bronchial glands as a dot or short line. The antibody also stained the intercellular borders of alveolar epithelia. In cancer cells that faced lumina of all adenocarcinomas, regardless of grade, including bronchioloalveolar carcinomas, occludin showed an expression pattern identical to that of the normal bronchial and alveolar epithelia. Occludin reactivity was not noted in any cases of squamous cell carcinoma, large cell carcinoma, small cell carcinoma, or large cell neuroendocrine carcinoma. The results of the present study suggest that occludin can se...Continue Reading

References

Jan 1, 1979·Annual Review of Physiology·J A NadelR J Phipps
May 18, 1979·Cell and Tissue Research·H Bartels
Feb 1, 1986·The American Journal of Physiology·G R CottR J Mason
Jan 1, 1985·Annual Review of Cell Biology·K Simons, S D Fuller
Jul 1, 1982·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·R J King
Oct 1, 1993·Current Opinion in Cell Biology·J M AndersonA S Fanning
Dec 1, 1993·The Journal of Cell Biology·M FuruseS Tsukita
Jan 20, 1999·Proceedings of the National Academy of Sciences of the United States of America·K MoritaS Tsukita
Mar 3, 2004·Human Pathology·Hirotoshi TobiokaNorimasa Sawada

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Citations

Apr 1, 2005·Pathology Oncology Research : POR·Gábor SobelZsuzsa Schaff
Jun 23, 2007·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Serge PaschoudSandra Citi
Oct 27, 2007·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Vassiliki N TzelepiChrisoula D Scopa
Sep 13, 2008·American Journal of Respiratory and Critical Care Medicine·Yu-Chih ChaoPan-Chyr Yang
Nov 19, 2009·Journal of Biomedicine & Biotechnology·Kieran BrennanAnn M Hopkins
May 15, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Keyi LiuRandall J Mrsny
May 16, 2007·Progress in Histochemistry and Cytochemistry·Lorenza González-MariscalErika Garay
Dec 9, 2008·Biochimica Et Biophysica Acta·Tracey A Martin, Wen G Jiang
Apr 10, 2007·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Judit MoldvayAndrás Kiss
Apr 4, 2015·Tissue Barriers·J M BrandnerA De Benedetto
Aug 23, 2016·Current Pathobiology Reports·Ellaine SalvadorCarola Y Förster
Mar 21, 2007·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Yuichi TokunagaNorimasa Sawada
Feb 12, 2017·Oncology Reports·André Luis Giacometti ConceiçãoPaula Rahal
Jun 15, 2019·International Journal of Molecular Medicine·Qiang ZhuJianyong Gao

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