Expression of olig2 in retinal progenitor cells

Neuroreport
Kazuaki NakamuraTakayuki Harada

Abstract

Olig2 is a basic helix-loop-helix transcription factor that is specifically expressed in oligodendrocyte precursors in the central nervous system. Owing to the absence of oligodendrocytes in the retina, however, the role of olig2 in retinal development remains unclear. In the present study, we demonstrated for the first time that olig2 is expressed in embryonic and postnatal mouse retina. Interestingly, a subset of the bromodeoxyuridine-positive cells expressed olig2 in the embryonic retina. On the other hand, olig2-positive cells did not express nestin, neuron-specific class III beta-tubulin, neurofilament, or various retinal cell-type-specific markers. These results suggest that olig2 is involved in the maintenance of the undifferentiated state of retinal progenitor cells.

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Citations

May 1, 2012·Proceedings of the National Academy of Sciences of the United States of America·Brian P HaflerConstance L Cepko
Feb 20, 2008·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Sawako KinjoYoichi Nakazato
May 29, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kiyo SakagamiXian-Jie Yang
Aug 7, 2014·Nature Reviews. Neuroscience·Connie Cepko
Jan 24, 2007·Developmental Biology·Maki AsamiMitsuko Kosaka
May 18, 2018·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Kate A MaurerNadean L Brown
Nov 24, 2015·Annual Review of Vision Science·Constance L Cepko

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