Expression of Oligodendrocyte Precursor Cell Markers in Canine Oligodendrogliomas

Veterinary Pathology
Takuya E KishimotoHiroyuki Nakayama

Abstract

Oligodendroglioma is a common brain tumor in dogs, particularly brachycephalic breeds. Oligodendrocyte precursor cells (OPCs) are suspected to be a possible origin of oligodendroglioma, although it has not been well elucidated. In the present study, 27 cases of canine brain oligodendrogliomas were histologically and immunohistochemically examined. The most commonly affected breed was the French Bulldog ( n = 19 of 27, 70%). Seizure was the most predominant clinical sign ( n = 17 of 25, 68%). The tumors were located mainly in the cerebrum, particularly in the frontal lobe ( n = 10 of 27, 37%). All cases were diagnosed as anaplastic oligodendroglioma (AO) and had common histologic features characterized by the proliferation of round to polygonal cells with pronounced atypia and conspicuous mitotic activity (average, 10.7 mitoses per 10 high-power fields). Honeycomb pattern ( n = 5 of 27, 19%), myxoid matrix ( n = 10, 37%), cyst formation ( n = 6, 22%), necrosis ( n = 19, 70%), pseudopalisading ( n = 5, 18.5%), glomeruloid vessels ( n = 16, 59%), and microcalcification ( n = 5, 19%) were other histopathologic features of the present tumors. Immunohistochemically, the tumor cells were positive for Olig2 in all cases and for other m...Continue Reading

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Citations

Dec 18, 2019·Veterinary Pathology·Ronja V KauerAnna Oevermann
Dec 6, 2019·Frontiers in Veterinary Science·Elena Alina DemeterAndrew D Miller
Dec 4, 2020·Journal of the American Veterinary Medical Association·Marc KentAndrew Miller
Mar 30, 2020·Molecular Therapy : the Journal of the American Society of Gene Therapy·Carolini KaidMayana Zatz
Jun 1, 2021·Veterinary Pathology·Hisashi YoshimuraToshiyuki Ishiwata

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