PMID: 8584018Oct 4, 1995Paper

Expression of ornithine decarboxylase in pancreatic development

Molecular and Cellular Biochemistry
P C Lee

Abstract

We examined the relationship between ornithine decarboxylase (ODC) and growth and differentiation in the developing rat exocrine pancreas. The ODC activity profile showed 2 distinct stages of increases with the first occurred at 14-16 days of age, and a second at 21-23 days of age. Growth parameters evaluated as gains in tissue mass, protein and DNA content in the pancreas indicated a low growth rate soon after birth with a transition to a much more rapid growth rate around the age of 20-21 days, a time corresponded to the second rise in ODC activity. Differentiation parameters evaluated as the accumulation of trypsinogen, amylase and lipase showed different temporal changes. While the rate of accumulation of all three enzymes was relatively low following birth, a rapid rate of accumulation of trypsinogen and amylase started around 15-16 days, a time corresponding to the first rise in ODC activity. Lipase, however, did not show an increase in its accumulation until around age 20 days. These results indicate that a rise in ODC activity is closely associated with growth and differentiation in the developing rat pancreas. To further examine this issue, the steady state levels of ODC mRNA in developing rats were evaluated by Northe...Continue Reading

References

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Citations

Jun 7, 2002·Journal of Pediatric Gastroenterology and Nutrition·Ping C LeeHershel Raff
Sep 3, 1999·Mechanisms of Development·M J NancarrowB C Powell
Dec 26, 2001·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·M T HowardJ F Atkins

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