Expression of osmotic stress protein 94 in murine endolymphatic hydrops model

Acta Oto-laryngologica
Chang-Hee KimYoung Ho Kim

Abstract

The up-regulation of osmotic stress protein 94 (OSP94) in the murine endolymphatic hydrops (EH) models suggests that OSP94 might be involved in cellular adaptation in response to ionic and osmotic stress in the murine inner ear. The purpose of the present study was to investigate the expression of OSP94 in cochlear tissues of the murine EH models and control animals. Nine adult BALB/c mice were treated with both intratympanic injection of lipopolysaccharide and intraperitoneal administration of aldosterone to induce EH. Nine mice were used as control animals. The expression level of OSP94 in the EH and control groups was compared using immunohistochemistry and real-time RT-PCR. Immunohistochemical staining of tissues in the EH group showed an up-regulation of OSP94 expression in the cochlea, especially in the stria vascularis and Reissner's membrane. Quantitative real-time PCR analysis also showed that transcription of the OSP94 gene in the cochlea was significantly up-regulated in the EH group.

References

Jan 1, 1991·Acta Oto-laryngologica. Supplementum·M M Paparella
Jun 1, 1990·The Annals of Otology, Rhinology & Laryngology. Supplement·D J LimT F DeMaria
Mar 1, 1982·The American Journal of Physiology·D D Macchia
Nov 1, 1982·American Journal of Otolaryngology·R S Kimura
Jan 1, 1994·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·W J ten CateK E Rarey
May 24, 1996·The Journal of Biological Chemistry·R KojimaS R Gullans
Jan 1, 1997·Acta Oto-laryngologica·E A DunnebierF W Albers
Aug 7, 1998·ORL; Journal for Oto-rhino-laryngology and Its Related Specialties·M TakumidaR Popa
May 25, 1999·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·K HisashiS Komiyama
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Dec 19, 2002·Otolaryngologic Clinics of North America·Michael M Paparella, Hamid R Djalilian
Apr 1, 2005·Acta Oto-laryngologica·Sebahattin CureogluMichael M Paparella
Aug 23, 2006·Molecular and Cellular Biology·Torsten HeldIbrahim M Adham
Sep 14, 2007·Acta Oto-laryngologica·Masaya TakumidaMatti Anniko

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Citations

Feb 26, 2016·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Rajasree Sreedharan, Scott K Van Why

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