PMID: 9638876Jun 25, 1998Paper

Expression of outer surface proteins A and C of Borrelia afzelii in Ixodes ricinus ticks and in the skin of mice

Zentralblatt Für Bakteriologie : International Journal of Medical Microbiology
S Leuba-GarciaL Gern

Abstract

Several studies have described changes in the expression of proteins, especially of OspA and OspC, of B. burgdorferi sensu stricto during tick feeding. In this study, the expression of OspA and OspC of B. afzelii in unfed and feeding I. ricinus nymphs and in the subsequent adults was followed by means of the immunofluorescence test. Spirochaetes expressing OspA and OspC were observed in 70% and 80%, respectively of the unfed nymphs. In feeding and in fully engorged ticks, spirochaetes expressed OspC, while OspA disappeared 24 hours after the beginning of the blood meal. Spirochaetes expressing OspC in salivary glands were observed in one engorged tick. After molting, in unfed adults spirochaetes again expressed OspA and OspC but did so less frequently (6% and 13%, respectively). The mouse strain (AKR/N or BALB/C) on which ticks had their infectious blood meal influenced OspC expression in the following tick stage. In the skin of AKR/N mice, at the tick feeding site, B. afzelii expressed OspC only, as was shown by immunostaining.

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Citations

Feb 24, 2001·Proceedings of the National Academy of Sciences of the United States of America·J OhnishiA M de Silva
Jun 18, 2002·Infection and Immunity·Emir HodzicStephen W Barthold
May 24, 2005·Infection and Immunity·Emir HodzicStephen W Barthold
Dec 13, 2006·Wiener klinische Wochenschrift·Brian StevensonTomasz Bykowski
Feb 3, 2007·International Journal of Medical Microbiology : IJMM·Volker FingerleUlrike Schulte-Spechtel
Jul 13, 2004·Arthritis and Rheumatism·Stephen BatsfordMichael Mihatsch
Jun 7, 2003·Molecular Microbiology·Janet AlversonD Scott Samuels
Jan 30, 2007·Molecular Microbiology·Michael A GilbertD Scott Samuels
May 16, 2007·Molecular Microbiology·Meghan C Lybecker, D Scott Samuels
Aug 2, 2011·Annual Review of Microbiology·D Scott Samuels
Oct 29, 2008·Evidence-based Complementary and Alternative Medicine : ECAM·Aristo VojdaniBernard Raxlen
Jun 9, 2005·Parasitology·J Piesman, L Gern
Jun 8, 2012·FEMS Immunology and Medical Microbiology·Laura L Hoon-HanksDan Drecktrah

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